HSF1 使 NK 细胞压力过大，无法做出反应

IF 17.3 1区生物学 Q1 CELL BIOLOGY

Nature Cell Biology Pub Date : 2024-09-02 DOI:10.1038/s41556-024-01472-1

Yael Gruper, Aviad Ben-Shmuel, Ruth Scherz-Shouval

引用次数: 0

摘要

肿瘤微环境会在常驻细胞中传播应激反应。在肿瘤浸润的自然杀伤（NK）细胞中，HSF1转录因子与效应器功能介质结合，对NK细胞毒性产生负面调节作用。这些发现提供了重要的机理启示，可能会加强NK细胞的癌症治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

HSF1 renders NK cells too stressed to respond

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HSF1 renders NK cells too stressed to respond

The tumour microenvironment propagates stress responses in resident cells. In tumour-infiltrating natural killer (NK) cells, the HSF1 transcription factor binds to mediators of effector function, negatively regulating NK cytotoxicity. These findings provide important mechanistic insights that may enhance NK cell cancer therapy.

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来源期刊

Nature Cell Biology 生物-细胞生物学

CiteScore

28.40

自引率

0.90%

发文量

219

审稿时长

3 months

期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology