造血细胞移植中的 HLA 结构和功能

IF 2.2 4区 医学 Q3 HEMATOLOGY
Effie W. Petersdorf
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引用次数: 0

摘要

自 50 多年前异体造血细胞移植术开展以来,患者与供体之间的 HLA 相合程度一直是供体选择的基础,并加深了人们对 HLA 基本免疫生物学的理解。新的证据支持患者和供体的种系变异发挥作用,这些变异不需要 HLA 匹配就能产生临床后果。新的非编码多态性、HLA 分子的结构特征和表达的发现为供体选择提供了新的模型,并激发了临床转化工具的开发。HLA配体/供体NK受体的配对效应可能在移植结果中发挥重要作用,并显示了了解NK通路的每个组成成分在调节供体对目标抗原的反应中所起作用的价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
HLA structure and function in hematopoietic-cell transplantation

The degree of HLA compatibility between a patient and donor has formed the basis of donor selection since the development of allogeneic hematopoietic cell transplantation over 50 years ago and has advanced understanding of the basic immunobiology of HLA. New evidence supports a role for germline variation in the patient and the donor that do not require HLA matching for their effects to have clinical consequences. The discovery of novel non-coding polymorphisms, structural features of HLA molecules, and expression provide new models for donor selection and inspire the development of tools for clinical translation. Pairwise effects of HLA ligand/donor NK receptors may play an important role in transplant outcomes and showcase the value of understanding the role played by each constituent of the NK pathway in modulating donor responses to target antigens.

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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
42
审稿时长
35 days
期刊介绍: Best Practice & Research Clinical Haematology publishes review articles integrating the results from the latest original research articles into practical, evidence-based review articles. These articles seek to address the key clinical issues of diagnosis, treatment and patient management. Each issue follows a problem-orientated approach which focuses on the key questions to be addressed, clearly defining what is known and not known, covering the spectrum of clinical and laboratory haematological practice and research. Although most reviews are invited, the Editor welcomes suggestions from potential authors.
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