光动力疗法作为口腔疣状癌微创治疗方法的潜力。

IF 3.1 3区医学 Q2 ONCOLOGY

Photodiagnosis and Photodynamic Therapy Pub Date : 2024-08-28 DOI:10.1016/j.pdpdt.2024.104320

Chen Li , Dandan Wang , Jian Ding

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引用次数: 0

摘要

口腔疣状癌（OVC）和增殖性疣状白斑（PVL）具有相似的组织学特征，并且可能有共同的起源。当它们同时出现时，增生性疣状白斑发生恶变的风险就会增加。对于患有这两种疾病的老年患者来说，安全、有效、简单、微创的治疗方法更可取。光动力疗法（PDT）是一种非侵入性治疗方法，它利用特定波长的光激活光敏剂，产生活性氧，选择性地针对恶性组织产生细胞毒性作用。本病例报告描述了一名同时患有大面积白斑病、PVL 和 OVC 的老年患者，在接受光动力疗法治疗 10 个月后，病情完全缓解且未复发。治疗取得了令人满意的临床效果，口腔的外观和功能都得到了保护。

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Potential of photodynamic therapy as a minimally invasive treatment for oral verrucous carcinoma

Oral verrucous carcinoma (OVC) and proliferative verrucous leukoplakia (PVL) share similar histological characteristics and may have a common origin. When they appear simultaneously, the risk of malignant transformation in PVL increases. In elderly patients with both conditions, a safe, effective, simple, and minimally invasive treatment is preferable. Photodynamic therapy (PDT), a non-invasive treatment, utilizes specific wavelengths of light to activate photosensitizers, generating reactive oxygen species that selectively target malignant tissues with cytotoxic effects. This case report describes an elderly patient with coexisting extensive leukoplakia, PVL, and OVC, who achieved complete remission with no recurrence at 10 months following PDT. The treatment resulted in a satisfactory clinical outcome, preserving both the appearance and function of the oral cavity.

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来源期刊

Photodiagnosis and Photodynamic Therapy ONCOLOGY-

CiteScore

5.80

自引率

24.20%

发文量

509

审稿时长

50 days

期刊介绍： Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.