氧氟沙星在耳鼻喉科的应用

G P Cavallo, C Giordano
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引用次数: 0

摘要

抗菌素耐药性的持续发展突出了对新的抗菌素药物的需求。尽管有许多新分子,但仍然需要有效的口服化合物。氟喹诺酮类药物是一类具有广谱抗菌活性的新型抗生素,包括耐药菌株和铜绿假单胞菌等难对付的微生物。氧氟沙星是一种可口服的氟喹诺酮类药物,具有良好的吸收性、高血药浓度和令人满意的组织渗透性,特别是在orl区。氧氟沙星200mg,每日2次,对几例患者(包括2例鼻炎)的治疗既安全又有效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[The use of ofloxacin in otorhinolaryngology].

Continuing development of antimicrobial resistance highlights the need for new antimicrobial agents. Despite many new molecules there is still a need for effective oral compounds. The fluoroquinolones are a new group of antibiotics with a wide spectrum of antibacterial activity which includes resistant strains and difficult microorganisms as Pseudomonas aeruginosa. Ofloxacin is a fluoroquinolone available for oral use showing good absorption with high blood levels and quite satisfactory tissue, penetration particularly in O.R.L. district. The treatment, consisting of ofloxacin 200 mg twice daily, of several patient (including two cases of rhinitis) was both safe and effective.

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