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引用次数: 0
摘要
相位变异是指基因表达的快速可逆转换,通常发生在小基因组细菌病原体的表面特征编码基因中。在缺乏多种 "感知-反应 "基因调控系统的细菌中,相位变异为它们提供了一种额外的生存机制。许多细菌病原体也编码具有相位变异的 DNA 甲基转移酶,其控制系统被称为 "相位变异调控子"(phasevarions)。这篇入门文章将总结目前对相位变异的理解,描述主要相位变异因子和相位变异子在细菌病理生物学中的作用。
Microbial Primer: Phase variation - survival and adaptability by generation of a diverse population.
Phase variation is defined as the rapid and reversible switching of gene expression, and typically occurs in genes encoding surface features in small genome bacterial pathogens. Phase variation has evolved to provide an extra survival mechanism in bacteria that lack multiple 'sense-and-respond' gene regulation systems. Many bacterial pathogens also encode DNA methyltransferases that are phase-variable, controlling systems called 'phasevarions' (phase-variable regulons). This primer will summarize the current understanding of phase variation, describing the role of major phase-variable factors, and phasevarions, in bacterial pathobiology.
期刊介绍:
We publish high-quality original research on bacteria, fungi, protists, archaea, algae, parasites and other microscopic life forms.
Topics include but are not limited to:
Antimicrobials and antimicrobial resistance
Bacteriology and parasitology
Biochemistry and biophysics
Biofilms and biological systems
Biotechnology and bioremediation
Cell biology and signalling
Chemical biology
Cross-disciplinary work
Ecology and environmental microbiology
Food microbiology
Genetics
Host–microbe interactions
Microbial methods and techniques
Microscopy and imaging
Omics, including genomics, proteomics and metabolomics
Physiology and metabolism
Systems biology and synthetic biology
The microbiome.