线粒体免疫检查点的代谢调节。

IF 6.5 2区医学 Q1 IMMUNOLOGY

Oncoimmunology Pub Date : 2024-08-26 eCollection Date: 2024-01-01 DOI:10.1080/2162402X.2024.2394247

David C Montrose, Suchandrima Saha, Lorenzo Galluzzi

引用次数: 0

摘要

破坏恶性细胞的线粒体功能是一种很有前景的增强抗癌免疫力的策略。我们最近证明，剥夺结直肠癌细胞中的丝氨酸会导致线粒体功能障碍以及线粒体 DNA 的胞浆积累，从而激活依赖 CGAS 和 STING 的肿瘤靶向免疫反应。

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Metabolic regulation of the mitochondrial immune checkpoint.

Disrupting mitochondrial function in malignant cells is a promising strategy to enhance anticancer immunity. We have recently demonstrated that depriving colorectal cancer cells of serine results in mitochondrial dysfunction coupled with the cytosolic accumulation of mitochondrial DNA and consequent activation of CGAS- and STING-dependent tumor-targeting immune responses.

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来源期刊

Oncoimmunology ONCOLOGYIMMUNOLOGY-IMMUNOLOGY

CiteScore

12.50

自引率

2.80%

发文量

276

审稿时长

24 weeks

期刊介绍： OncoImmunology is a dynamic, high-profile, open access journal that comprehensively covers tumor immunology and immunotherapy. As cancer immunotherapy advances, OncoImmunology is committed to publishing top-tier research encompassing all facets of basic and applied tumor immunology. The journal covers a wide range of topics, including: -Basic and translational studies in immunology of both solid and hematological malignancies -Inflammation, innate and acquired immune responses against cancer -Mechanisms of cancer immunoediting and immune evasion -Modern immunotherapies, including immunomodulators, immune checkpoint inhibitors, T-cell, NK-cell, and macrophage engagers, and CAR T cells -Immunological effects of conventional anticancer therapies.