Olushola Abdulrahman Afolabi, Segun Segun-Busari, Habeeb Kayodele Omokanye, Muritala Jimoh, Iheayi O Iheagwu, Wasiu Omotosho, Saad O Idris, Kenechukwu Uche-Okonkwo, Biodun Sulyman Alabi, Adekunle David Dunmade, Foluwasayo E Ologe
{"title":"尼日利亚中北部伊洛林慢性鼻窦炎患者的鼻黏膜清除时间。","authors":"Olushola Abdulrahman Afolabi, Segun Segun-Busari, Habeeb Kayodele Omokanye, Muritala Jimoh, Iheayi O Iheagwu, Wasiu Omotosho, Saad O Idris, Kenechukwu Uche-Okonkwo, Biodun Sulyman Alabi, Adekunle David Dunmade, Foluwasayo E Ologe","doi":"10.4103/npmj.npmj_10_24","DOIUrl":null,"url":null,"abstract":"<p><strong>Context: </strong>The mucociliary clearance system is an important component in the prevention of chronic inflammation of the nasal and paranasal sinus.</p><p><strong>Aim: </strong>The study aims to establish the normal values of mucociliary clearance in our region and to study the variation in mucociliary activity in patients with chronic rhinosinusitis in Ilorin, North-central Nigeria.</p><p><strong>Settings and design: </strong>This was a prospective, cross-sectional study using consecutive consenting participants in both the control and study groups carried out at both family medicine and otorhinolaryngology clinics among patients attending the clinics.</p><p><strong>Subjects and methods: </strong>After ethical approval was sought, informed consent was obtained from patients, a modified version of the validated health questionnaire was filled, semi-structured questionnaires were also filled after which patient undergo anterior rhinoscopy, nasal patency test and spirometry was done. The saccharine test has been used to measure nasal-mucociliary clearance time in the past.</p><p><strong>Statistical analysis: </strong>All information were entered into SPSS version 20 and analysed descriptively, and results were presented in tables and figures.</p><p><strong>Results: </strong>Consecutive consenting 125 patients with rhinosinusitis (study group) and those without rhinosinusitis (control group) underwent naso-mucociliary clearance test. There were 34 males and 91 females with a male:female ratio of 1:2.6 among the study group and 55 males and 70 females with a male:female ratio of 1:1.3 for the control group. The age range was from 18 to 68 years with 18-40 years constituting the modal age group. The mean age for the studied group was 35.7 years while that of the control group was 33.1 years. The mean naso-mucociliary clearance time among the study group was 35.1 min standard deviation (SD = 12.32 ± 1.63), while among the control group, it was 14.8 min (SD = 5.59 ± 0.43).</p><p><strong>Conclusion: </strong>Compared to the control group, there was a roughly 200% prolonged increase in the duration of naso-mucociliary clearance time among patients with rhinosinusitis. There was also a positive correlation with increasing age. Future studies comparing the pre-operative and post-operative treatment of rhinosinusitis will contribute to knowledge.</p>","PeriodicalId":19720,"journal":{"name":"Nigerian Postgraduate Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Naso-mucociliary Clearance Time among Patients with Chronic Rhinosinusitis in Ilorin, North-central Nigeria.\",\"authors\":\"Olushola Abdulrahman Afolabi, Segun Segun-Busari, Habeeb Kayodele Omokanye, Muritala Jimoh, Iheayi O Iheagwu, Wasiu Omotosho, Saad O Idris, Kenechukwu Uche-Okonkwo, Biodun Sulyman Alabi, Adekunle David Dunmade, Foluwasayo E Ologe\",\"doi\":\"10.4103/npmj.npmj_10_24\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Context: </strong>The mucociliary clearance system is an important component in the prevention of chronic inflammation of the nasal and paranasal sinus.</p><p><strong>Aim: </strong>The study aims to establish the normal values of mucociliary clearance in our region and to study the variation in mucociliary activity in patients with chronic rhinosinusitis in Ilorin, North-central Nigeria.</p><p><strong>Settings and design: </strong>This was a prospective, cross-sectional study using consecutive consenting participants in both the control and study groups carried out at both family medicine and otorhinolaryngology clinics among patients attending the clinics.</p><p><strong>Subjects and methods: </strong>After ethical approval was sought, informed consent was obtained from patients, a modified version of the validated health questionnaire was filled, semi-structured questionnaires were also filled after which patient undergo anterior rhinoscopy, nasal patency test and spirometry was done. The saccharine test has been used to measure nasal-mucociliary clearance time in the past.</p><p><strong>Statistical analysis: </strong>All information were entered into SPSS version 20 and analysed descriptively, and results were presented in tables and figures.</p><p><strong>Results: </strong>Consecutive consenting 125 patients with rhinosinusitis (study group) and those without rhinosinusitis (control group) underwent naso-mucociliary clearance test. There were 34 males and 91 females with a male:female ratio of 1:2.6 among the study group and 55 males and 70 females with a male:female ratio of 1:1.3 for the control group. The age range was from 18 to 68 years with 18-40 years constituting the modal age group. The mean age for the studied group was 35.7 years while that of the control group was 33.1 years. The mean naso-mucociliary clearance time among the study group was 35.1 min standard deviation (SD = 12.32 ± 1.63), while among the control group, it was 14.8 min (SD = 5.59 ± 0.43).</p><p><strong>Conclusion: </strong>Compared to the control group, there was a roughly 200% prolonged increase in the duration of naso-mucociliary clearance time among patients with rhinosinusitis. There was also a positive correlation with increasing age. Future studies comparing the pre-operative and post-operative treatment of rhinosinusitis will contribute to knowledge.</p>\",\"PeriodicalId\":19720,\"journal\":{\"name\":\"Nigerian Postgraduate Medical Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nigerian Postgraduate Medical Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/npmj.npmj_10_24\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/9/2 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nigerian Postgraduate Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/npmj.npmj_10_24","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/2 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Naso-mucociliary Clearance Time among Patients with Chronic Rhinosinusitis in Ilorin, North-central Nigeria.
Context: The mucociliary clearance system is an important component in the prevention of chronic inflammation of the nasal and paranasal sinus.
Aim: The study aims to establish the normal values of mucociliary clearance in our region and to study the variation in mucociliary activity in patients with chronic rhinosinusitis in Ilorin, North-central Nigeria.
Settings and design: This was a prospective, cross-sectional study using consecutive consenting participants in both the control and study groups carried out at both family medicine and otorhinolaryngology clinics among patients attending the clinics.
Subjects and methods: After ethical approval was sought, informed consent was obtained from patients, a modified version of the validated health questionnaire was filled, semi-structured questionnaires were also filled after which patient undergo anterior rhinoscopy, nasal patency test and spirometry was done. The saccharine test has been used to measure nasal-mucociliary clearance time in the past.
Statistical analysis: All information were entered into SPSS version 20 and analysed descriptively, and results were presented in tables and figures.
Results: Consecutive consenting 125 patients with rhinosinusitis (study group) and those without rhinosinusitis (control group) underwent naso-mucociliary clearance test. There were 34 males and 91 females with a male:female ratio of 1:2.6 among the study group and 55 males and 70 females with a male:female ratio of 1:1.3 for the control group. The age range was from 18 to 68 years with 18-40 years constituting the modal age group. The mean age for the studied group was 35.7 years while that of the control group was 33.1 years. The mean naso-mucociliary clearance time among the study group was 35.1 min standard deviation (SD = 12.32 ± 1.63), while among the control group, it was 14.8 min (SD = 5.59 ± 0.43).
Conclusion: Compared to the control group, there was a roughly 200% prolonged increase in the duration of naso-mucociliary clearance time among patients with rhinosinusitis. There was also a positive correlation with increasing age. Future studies comparing the pre-operative and post-operative treatment of rhinosinusitis will contribute to knowledge.