间充质干细胞的线粒体转移：机制与功能。

IF 3.9 3区生物学 Q2 CELL BIOLOGY

Mitochondrion Pub Date : 2024-08-31 DOI:10.1016/j.mito.2024.101950

Qing Liu , Xiaoxin Zhang , Tongxin Zhu , Zhonghan Xu , Yingchun Dong , Bin Chen

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引用次数: 0

摘要

间充质干细胞疗法应用于临床已近20年，在治疗多种疾病方面取得了令人鼓舞的效果。然而，其潜在的机制远比之前假设的要复杂得多。线粒体转移是间充质干细胞最近发现的一种发挥生物效应的方式。作为线粒体成分交换的一种方式，线粒体转移决定了间充质干细胞和受体细胞的命运。在这篇综述中，我们将介绍促进间充质干细胞线粒体转移的因素。然后，总结了间充质干细胞-间变性的途径和机制，为间充质干细胞治疗提供理论依据。此外，还分析了间充质干细胞-间充质干细胞在临床应用中的优缺点。

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Mitochondrial transfer from mesenchymal stem cells: Mechanisms and functions

Mesenchymal stem cells based therapy has been used in clinic for almost 20 years and has shown encouraging effects in treating a wide range of diseases. However, the underlying mechanism is far more complicated than it was previously assumed. Mitochondria transfer is one way that recently found to be employed by mesenchymal stem cells to exert its biological effects. As one way of exchanging mitochondrial components, mitochondria transfer determines both mesenchymal stem cells and recipient cell fates. In this review, we describe the factors that contribute to MSCs-MT. Then, the routes and mechanisms of MSCs-MT are summarized to provide a theoretical basis for MSCs therapy. Besides, the advantages and disadvantages of MSCs-MT in clinical application are analyzed.

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来源期刊

Mitochondrion 生物-细胞生物学

CiteScore

9.40

自引率

4.50%

发文量

审稿时长

13.6 weeks

期刊介绍： Mitochondrion is a definitive, high profile, peer-reviewed international research journal. The scope of Mitochondrion is broad, reporting on basic science of mitochondria from all organisms and from basic research to pathology and clinical aspects of mitochondrial diseases. The journal welcomes original contributions from investigators working in diverse sub-disciplines such as evolution, biophysics, biochemistry, molecular and cell biology, genetics, pharmacology, toxicology, forensic science, programmed cell death, aging, cancer and clinical features of mitochondrial diseases.