Shu Xiao, Zibin Yang, Zitao Lin, Liqing Chen, Weiming Liao, Jurong Wang, Cuihua Gao, Jianjun Lu, Yang Song, Sulian Su, Guihua Jiang
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The results of individual neuroimaging studies of TLE, however, are frequently inconsistent due to small and heterogeneous samples, analytical flexibility, and publication bias toward positive findings.</p><p><strong>Purpose: </strong>To investigate the most consistent regions of resting-state functional brain activity abnormality in patients with TLE through a quantitative meta-analysis of published neuroimaging data.</p><p><strong>Study type: </strong>Meta-analysis.</p><p><strong>Subjects: </strong>Exactly 1474 TLE patients (716 males and 758 females) from 31 studies on resting-state functional brain activity were included in this study.</p><p><strong>Field strength/sequence: </strong>Studies utilizing 1.5 T or 3 T MR scanners were included for meta-analysis. Resting-state functional MRI using gradient echo-planar imaging, T1-weighted imaging.</p><p><strong>Assessment: </strong>PubMed, Web of Science, Chinese National Knowledge Infrastructure, and WanFang databases were searched to identify studies investigating amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) at the whole-brain level between patients with TLE and healthy controls (HCs).</p><p><strong>Statistical tests: </strong>Seed-based d Mapping with Permutation of Subject Images, standard randomization tests and meta-regression analysis were used. Results were significant if P < 0.05 with family-wise error corrected.</p><p><strong>Results: </strong>Patients with TLE displayed resting-state functional brain activity which was a significant increase in the right hippocampus, and significant decrease in the right angular gurus and right precuneus. Additionally, the meta-regression analysis demonstrated that age (P = 0.231), sex distribution (P = 0.376), and illness duration (P = 0.184), did not show significant associations with resting state functional brain activity in patients with TLE.</p><p><strong>Data conclusion: </strong>Common alteration patterns of spontaneous brain activity were identified in the right hippocampus and default-model network regions in patients with TLE. These findings may contribute to understanding of the underlying mechanism for potentially effective intervention of TLE.</p><p><strong>Level of evidence: 1: </strong></p><p><strong>Technical efficacy stage: </strong>Stage 2.</p>","PeriodicalId":16140,"journal":{"name":"Journal of Magnetic Resonance Imaging","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Spontaneous Brain Activity Abnormalities in Patients With Temporal Lobe Epilepsy: A Meta-Analysis of 1474 Patients.\",\"authors\":\"Shu Xiao, Zibin Yang, Zitao Lin, Liqing Chen, Weiming Liao, Jurong Wang, Cuihua Gao, Jianjun Lu, Yang Song, Sulian Su, Guihua Jiang\",\"doi\":\"10.1002/jmri.29568\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Abnormalities in resting-state functional brain activity have been detected in patients with temporal lobe epilepsy (TLE). The results of individual neuroimaging studies of TLE, however, are frequently inconsistent due to small and heterogeneous samples, analytical flexibility, and publication bias toward positive findings.</p><p><strong>Purpose: </strong>To investigate the most consistent regions of resting-state functional brain activity abnormality in patients with TLE through a quantitative meta-analysis of published neuroimaging data.</p><p><strong>Study type: </strong>Meta-analysis.</p><p><strong>Subjects: </strong>Exactly 1474 TLE patients (716 males and 758 females) from 31 studies on resting-state functional brain activity were included in this study.</p><p><strong>Field strength/sequence: </strong>Studies utilizing 1.5 T or 3 T MR scanners were included for meta-analysis. Resting-state functional MRI using gradient echo-planar imaging, T1-weighted imaging.</p><p><strong>Assessment: </strong>PubMed, Web of Science, Chinese National Knowledge Infrastructure, and WanFang databases were searched to identify studies investigating amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) at the whole-brain level between patients with TLE and healthy controls (HCs).</p><p><strong>Statistical tests: </strong>Seed-based d Mapping with Permutation of Subject Images, standard randomization tests and meta-regression analysis were used. Results were significant if P < 0.05 with family-wise error corrected.</p><p><strong>Results: </strong>Patients with TLE displayed resting-state functional brain activity which was a significant increase in the right hippocampus, and significant decrease in the right angular gurus and right precuneus. Additionally, the meta-regression analysis demonstrated that age (P = 0.231), sex distribution (P = 0.376), and illness duration (P = 0.184), did not show significant associations with resting state functional brain activity in patients with TLE.</p><p><strong>Data conclusion: </strong>Common alteration patterns of spontaneous brain activity were identified in the right hippocampus and default-model network regions in patients with TLE. 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引用次数: 0
摘要
背景：在颞叶癫痫（TLE）患者中发现了静息态大脑功能活动异常。目的：通过对已发表的神经影像学数据进行定量荟萃分析，研究颞叶癫痫患者静息态脑功能活动异常最一致的区域：研究类型：荟萃分析：本研究共纳入了31项静息态脑功能活动研究中的1474名TLE患者（716名男性和758名女性）：荟萃分析纳入了使用 1.5 T 或 3 T MR 扫描仪的研究。静息态功能磁共振成像采用梯度回波平面成像、T1加权成像：在PubMed、Web of Science、Chinese National Knowledge Infrastructure和万方数据库中进行检索，以确定调查TLE患者和健康对照组（HCs）之间全脑水平的低频波动幅度（ALFF）、分数ALFF（fALFF）和区域同质性（ReHo）的研究：统计检验：采用基于种子的受试者图像迭代d映射、标准随机检验和元回归分析。如果 P 结果为显著，则结果为显著：TLE患者的静息态脑功能活动表现为右侧海马显著增加，右侧角弓反张和右侧楔前显著减少。此外，元回归分析表明，年龄（P = 0.231）、性别分布（P = 0.376）和病程（P = 0.184）与 TLE 患者的静息态脑功能活动无明显关联：数据结论：在TLE患者的右侧海马体和默认模型网络区域发现了自发脑活动的共同改变模式。这些发现有助于了解TLE的潜在有效干预机制：1：技术疗效阶段：证据等级：1：技术疗效阶段：第2阶段。
Spontaneous Brain Activity Abnormalities in Patients With Temporal Lobe Epilepsy: A Meta-Analysis of 1474 Patients.
Background: Abnormalities in resting-state functional brain activity have been detected in patients with temporal lobe epilepsy (TLE). The results of individual neuroimaging studies of TLE, however, are frequently inconsistent due to small and heterogeneous samples, analytical flexibility, and publication bias toward positive findings.
Purpose: To investigate the most consistent regions of resting-state functional brain activity abnormality in patients with TLE through a quantitative meta-analysis of published neuroimaging data.
Study type: Meta-analysis.
Subjects: Exactly 1474 TLE patients (716 males and 758 females) from 31 studies on resting-state functional brain activity were included in this study.
Field strength/sequence: Studies utilizing 1.5 T or 3 T MR scanners were included for meta-analysis. Resting-state functional MRI using gradient echo-planar imaging, T1-weighted imaging.
Assessment: PubMed, Web of Science, Chinese National Knowledge Infrastructure, and WanFang databases were searched to identify studies investigating amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) at the whole-brain level between patients with TLE and healthy controls (HCs).
Statistical tests: Seed-based d Mapping with Permutation of Subject Images, standard randomization tests and meta-regression analysis were used. Results were significant if P < 0.05 with family-wise error corrected.
Results: Patients with TLE displayed resting-state functional brain activity which was a significant increase in the right hippocampus, and significant decrease in the right angular gurus and right precuneus. Additionally, the meta-regression analysis demonstrated that age (P = 0.231), sex distribution (P = 0.376), and illness duration (P = 0.184), did not show significant associations with resting state functional brain activity in patients with TLE.
Data conclusion: Common alteration patterns of spontaneous brain activity were identified in the right hippocampus and default-model network regions in patients with TLE. These findings may contribute to understanding of the underlying mechanism for potentially effective intervention of TLE.
期刊介绍：
The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.
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