美国男性血浆致动脉粥样硬化指数与勃起功能障碍之间的关系:一项基于人群的横断面研究。

IF 2.8 3区 医学 Q2 UROLOGY & NEPHROLOGY
Guodong Liu, Yuyang Zhang, Xu Wu, Wei Zhang, Hui Jiang, Xiansheng Zhang
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引用次数: 0

摘要

勃起功能障碍(ED)与心血管疾病(CVD)有关,涉及动脉粥样硬化和内皮功能障碍等风险因素。由于血浆致动脉粥样硬化指数(AIP)可能对预测心血管风险有潜在价值,我们利用大规模数据对AIP和ED之间的关系进行了全面分析,并探讨了其对临床和未来研究的潜在影响。我们使用 R 软件筛选了美国国家健康与营养调查(NHANES)数据库,选择了两个研究周期的数据集进行横断面分析,加入了协变量,并使用多变量逻辑回归进行了统计分析。此外,还进行了敏感性分析,并使用广义加性模型回归和平滑曲线拟合进一步评估了AIP指数与ED之间的关系。在对 21 161 名参与者进行初步筛选后,1503 名参与者被纳入其中,ED 组的 AIP 水平为 0.21 ± 0.02,而无 ED 组的 AIP 水平为 0.08 ± 0.01。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Association between the atherogenic index of plasma and erectile dysfunction in US men: a population-based cross-sectional study.

Association between the atherogenic index of plasma and erectile dysfunction in US men: a population-based cross-sectional study.

Erectile dysfunction (ED) is associated with cardiovascular disease (CVD) and involves risk factors such as atherosclerosis and endothelial dysfunction. Since the atherogenic index of plasma (AIP) may be potentially valuable in predicting cardiovascular risk, we conducted a comprehensive analysis of the relationship between AIP and ED using large-scale data, as well as exploring its potential implications for clinical and future research. We screened the National Health and Nutrition Examination Survey (NHANES) database using R software, selected datasets from two study cycles for cross-sectional analysis, enrolled covariates and performed statistical analyses using multivariate logistic regression. Furthermore, sensitivity analyses were performed and the relationship between the AIP index and ED was further assessed using generalized additive model regression and smoothed curve fitting. After an initial filter of 21,161 participants, 1503 participants were included, and the AIP level in the ED group was 0.21 ± 0.02 compared with 0.08 ± 0.01 in the group without ED, which was analyzed to show a statistically significant difference between them (P < 0.0001), and the difference was further confirmed in the sensitivity analyses. We suggest that early assessment, intervention, and individualized treatment of ED in people with high AIP levels is warranted, as it not only improves sexual function but also reduces the risk of CVD. However, it was a limitation of this study that the study population was all from the US, and more research is needed in the future to elucidate the causal relationship between AIP and ED and the association in a wider population.

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来源期刊
International Journal of Impotence Research
International Journal of Impotence Research 医学-泌尿学与肾脏学
CiteScore
4.90
自引率
19.20%
发文量
140
审稿时长
>12 weeks
期刊介绍: International Journal of Impotence Research: The Journal of Sexual Medicine addresses sexual medicine for both genders as an interdisciplinary field. This includes basic science researchers, urologists, endocrinologists, cardiologists, family practitioners, gynecologists, internists, neurologists, psychiatrists, psychologists, radiologists and other health care clinicians.
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