心脏组织工程:治疗心力衰竭的新兴方法。

IF 4.3 3区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Frontiers in Bioengineering and Biotechnology Pub Date : 2024-08-15 eCollection Date: 2024-01-01 DOI:10.3389/fbioe.2024.1441933
Hossein Rayat Pisheh, Fatemeh Sadat Nojabaei, Ahmad Darvishi, Ali Rayat Pisheh, Mahsa Sani
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引用次数: 0

摘要

心力衰竭是一种主要的健康问题,心脏无法泵出足够的血液来满足身体的需要。它是一种渐进性疾病,随着时间的推移会变得越来越严重,可由多种因素引起,包括心脏病发作、心肌病和心脏瓣膜病。目前有多种方法可以治愈这种具有多种并发症和风险的疾病。知识和技术的进步为许多疾病提出了新的治疗方法。组织工程学是治疗心力衰竭最有前途的新方法之一。组织工程是一个研究领域,旨在创造活的组织和器官,以替代受损或病变的组织。组织工程治疗心衰的目标是改善心脏功能,减少心脏移植的需要。可以利用细胞、生物材料和信号这三个重要原理来改善心脏功能或替代心脏组织。使用细胞和生物材料的技术多种多样,如电纺丝、水凝胶合成、脱细胞等。通过组织工程治疗心力衰竭仍在开发和研究中,但希望在不久的将来不再需要移植或侵入性手术。在本研究中,我们将以近年来最重要的研究为基础,探讨组织工程在治疗心力衰竭方面的力量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cardiac tissue engineering: an emerging approach to the treatment of heart failure.

Heart failure is a major health problem in which the heart is unable to pump enough blood to meet the body's needs. It is a progressive disease that becomes more severe over time and can be caused by a variety of factors, including heart attack, cardiomyopathy and heart valve disease. There are various methods to cure this disease, which has many complications and risks. The advancement of knowledge and technology has proposed new methods for many diseases. One of the promising new treatments for heart failure is tissue engineering. Tissue engineering is a field of research that aims to create living tissues and organs to replace damaged or diseased tissue. The goal of tissue engineering in heart failure is to improve cardiac function and reduce the need for heart transplantation. This can be done using the three important principles of cells, biomaterials and signals to improve function or replace heart tissue. The techniques for using cells and biomaterials such as electrospinning, hydrogel synthesis, decellularization, etc. are diverse. Treating heart failure through tissue engineering is still under development and research, but it is hoped that there will be no transplants or invasive surgeries in the near future. In this study, based on the most important research in recent years, we will examine the power of tissue engineering in the treatment of heart failure.

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来源期刊
Frontiers in Bioengineering and Biotechnology
Frontiers in Bioengineering and Biotechnology Chemical Engineering-Bioengineering
CiteScore
8.30
自引率
5.30%
发文量
2270
审稿时长
12 weeks
期刊介绍: The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs. In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.
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