乳腺癌免疫疗法的最新进展:综述。

IF 3.3 4区 医学 Q2 ONCOLOGY
Breast Cancer : Targets and Therapy Pub Date : 2024-08-27 eCollection Date: 2024-01-01 DOI:10.2147/BCTT.S482504
Qian-Er Wen, Liang Li, Rui-Qi Feng, De-Hui Li, Chang Qiao, Xiao-Song Xu, Yan-Jing Zhang
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引用次数: 0

摘要

乳腺癌是世界上女性最常见的恶性肿瘤之一,其发病率呈逐年上升趋势,严重威胁着女性的身心健康。三阴性乳腺癌(TNBC)是雌激素受体、孕激素受体和人表皮生长因子受体-2均为阴性的一种特殊的乳腺癌分子类型。与其他分子类型的乳腺癌相比,三阴性乳腺癌(TNBC)具有侵袭性和转移性强、复发率高、缺乏有效治疗靶点等特点,临床治疗效果通常较差。化疗是过去的主要治疗手段。随着免疫时代的到来,免疫治疗在三阴性乳腺癌(TNBC)的治疗中取得了很大进展,为三阴性乳腺癌的治疗带来了新的希望。本综述结合前沿医学研究成果,主要总结了免疫治疗的研究进展,归纳了三阴性乳腺癌(TNBC)免疫治疗的主要治疗方法,包括免疫检查点抑制剂、肿瘤疫苗、采用性免疫治疗和中西医结合应用等。为三阴性乳腺癌(TNBC)的治疗提供了新思路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recent Advances in Immunotherapy for Breast Cancer: A Review.

Breast cancer is one of the most common malignant tumors in women in the world, and its incidence is increasing year by year, which seriously threatens the physical and mental health of women. Triple negative breast cancer (TNBC) is a special molecular type of breast cancer in which estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 are negative. Compared with other molecular types of breast cancer, triple-negative breast cancer (TNBC) has high aggressiveness and metastasis, high recurrence rate, lack of effective therapeutic targets, and usually poor clinical treatment effect. Chemotherapy was the main therapeutic means used in the past. With the advent of the immune era, immunotherapy has made a lot of progress in the treatment of triple-negative breast cancer (TNBC), bringing new therapeutic hope for the treatment of triple-negative breast cancer. This review combines the results of cutting-edge medical research, mainly summarizes the research progress of immunotherapy, and summarizes the main treatment methods of triple-negative breast cancer (TNBC) immunotherapy, including immune checkpoint inhibitors, tumor vaccines, adoptive immunotherapy and the application of traditional Chinese and western medicine. It provides a new idea for the treatment of triple negative breast cancer (TNBC).

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来源期刊
CiteScore
4.10
自引率
0.00%
发文量
40
审稿时长
16 weeks
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