"胎儿和母体免疫耐受中的细胞外囊泡

IF 4.1 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomedical Journal Pub Date : 2024-08-29 DOI:10.1016/j.bj.2024.100785

William J. Burlingham

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引用次数: 0

摘要

胎儿与母体共存期间的异体耐受有两个关键问题：1) 异体耐受的重点必须是局部的，使母体的外周免疫能力能够继续全面抵抗病原体；2) 异体耐受必须自我传播，即不断为局部耐受状态招募新的增援。这两个问题都可以通过 Tregs 和 Bregs 的外泌体途径来解决。虽然胎儿和母体在妊娠期的适应性在胎儿娩出时终止，但地理、气候和母婴周围环境中的地方性病原体将决定他们之间免疫互动的短期和长期影响。

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Extracellular vesicles in fetal-maternal immune tolerance

Two key problems of allo-tolerance during fetal-maternal co-existence are: 1) it's focus must be local, allowing the mother's continued peripheral immune competence to resist pathogens ubiquitously, and 2) it must propagate itself, i.e. continuously recruit new re-enforcements of the local tolerant state. Both are solved by the exosomal pathway of Tregs & Bregs. While the fetal-maternal accomodations of pregnancy terminate at the time of partrurition, geography, climate and the endemic pathogens of the environment surrounding the mother-baby pair would then define the short and long-term effects of their immunologic interaction.

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来源期刊

Biomedical Journal Medicine-General Medicine

CiteScore

11.60

自引率

1.80%

发文量

128

审稿时长

42 days

期刊介绍： Biomedical Journal publishes 6 peer-reviewed issues per year in all fields of clinical and biomedical sciences for an internationally diverse authorship. Unlike most open access journals, which are free to readers but not authors, Biomedical Journal does not charge for subscription, submission, processing or publication of manuscripts, nor for color reproduction of photographs. Clinical studies, accounts of clinical trials, biomarker studies, and characterization of human pathogens are within the scope of the journal, as well as basic studies in model species such as Escherichia coli, Caenorhabditis elegans, Drosophila melanogaster, and Mus musculus revealing the function of molecules, cells, and tissues relevant for human health. However, articles on other species can be published if they contribute to our understanding of basic mechanisms of biology. A highly-cited international editorial board assures timely publication of manuscripts. Reviews on recent progress in biomedical sciences are commissioned by the editors.