Yi Yang, Junping Su, Timothe Guerin, Martin Nielsen, Anis Tlili
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引用次数: 0
摘要
在本研究中,我们首次发现甲酸盐可作为双功能试剂用于苯酚衍生物的合成,也可作为 COware 气体反应器在无活化条件下用于羰基交叉偶联过程的 CO 源。成功的关键是在蓝光 LED 的照射下,通过前所未有的镍/有机光催化剂系统原位合成了甲酸芳基酯。所开发的这一系统非常适用于合成苯酚衍生物的各种芳基碘化物基质。此外,生成的一氧化碳还可用于一系列 C-杂原子和 C-C 的羰基化过程。值得注意的是,市售的 H13COONa 盐可以作为一种双功能试剂,既能合成苯酚,又能生成 13CO。
Formate Salt as a Bifunctional Reagent for Hydroxylation and Carbonylation Reactions Under Photochemically Driven Nickel Catalysis.
In this study, we disclose for the first time that formate salt can be used as a bifunctional reagent for the synthesis of phenol derivatives and as a CO source for carbonylative cross-coupling processes using the COware gas reactor under activation free conditions. Key to this success is the in-situ synthesis of aryl formate via an unprecedented nickel/organophotocatalyst system under blue LED irradiation. This developed system demonstrated high applicability to various aryl iodide substrates for synthesizing phenol derivatives. Moreover, the generated CO could be utilized in a range of carbonylative C-heteroatom and C-C processes. Notably, commercially available H13COONa salt can serve as a bifunctional reagent for both synthesizing phenols and generating 13CO.
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