Benjamin Sommer Thinggaard , Yousif Subhi , Fadumo Abdullah Ismail , Maria Pedersen , Lars Morsø , Jakob Grauslund , Lonny Stokholm
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Such information might be invaluable for healthcare providers, enabling them to understand who benefits from treatment.</p></div><div><h3>Design</h3><p>Survey-based cross-sectional study</p></div><div><h3>Methods</h3><p>We used questionnaire responses from patients receiving intravitreal anti-VEGF injections for nAMD to evaluate self-reported QoL, measured by the Macular Degeneration Quality of Life questionnaire. Background questions in the survey gathered patient information, while BCVA was obtained from medical records. The associations between self-rated QoL and various factors were analyzed using binomial logistic regression and linear regression. We calculated crude odds ratio (OR) and β-coefficient as well as OR and β-coefficient adjusted for sex, age, and BCVA.</p></div><div><h3>Results</h3><p>This study included 348 individuals, median age 79.2 years (IQR 75.0–84.0), with 58.3 % women. In the adjusted logistic model, factors associated with a QoL above average were male sex (OR 1.65, 95 % CI 1.04, 2.63), BCVA above 0.5 Snellen in best seeing eye (OR 11.16, 95 % CI 4.24, 29.35), preserved driving ability (OR 3.35, 95 % CI 1.80, 6.26), and perceiving treatment effectiveness (OR 2.15, 95 % CI 1.07, 4.34). The adjusted linear regression revealed the same associations, yet the positive relationship between QoL and biological sex was significant in the crude model but not in the adjusted model (β: 0.30, 95 % CI -0.04, 0.64).</p></div><div><h3>Conclusion</h3><p>Good visual acuity and driving ability strongly correlate with high QoL in patients with nAMD. Perceptions of the effectiveness of anti-VEGF treatment double the likelihood of high QoL, highlighting the need for further investigation into its potential clinical implications.</p></div>","PeriodicalId":100071,"journal":{"name":"AJO International","volume":"1 3","pages":"Article 100066"},"PeriodicalIF":0.0000,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950253524000662/pdfft?md5=56384a5249e24af4818a8efb5b27b373&pid=1-s2.0-S2950253524000662-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Factors affecting quality of life in patients with neovascular age-related macular degeneration\",\"authors\":\"Benjamin Sommer Thinggaard , Yousif Subhi , Fadumo Abdullah Ismail , Maria Pedersen , Lars Morsø , Jakob Grauslund , Lonny Stokholm\",\"doi\":\"10.1016/j.ajoint.2024.100066\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>This study examines how factors such as age, sex, best corrected visual acuity (BCVA), driving ability, and perceived treatment effectiveness influence quality of life (QoL) among patients with neovascular age-related macular degeneration (nAMD) in treatment with anti-vascular endothelial growth factor (VEGF) injections. Such information might be invaluable for healthcare providers, enabling them to understand who benefits from treatment.</p></div><div><h3>Design</h3><p>Survey-based cross-sectional study</p></div><div><h3>Methods</h3><p>We used questionnaire responses from patients receiving intravitreal anti-VEGF injections for nAMD to evaluate self-reported QoL, measured by the Macular Degeneration Quality of Life questionnaire. Background questions in the survey gathered patient information, while BCVA was obtained from medical records. The associations between self-rated QoL and various factors were analyzed using binomial logistic regression and linear regression. We calculated crude odds ratio (OR) and β-coefficient as well as OR and β-coefficient adjusted for sex, age, and BCVA.</p></div><div><h3>Results</h3><p>This study included 348 individuals, median age 79.2 years (IQR 75.0–84.0), with 58.3 % women. 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引用次数: 0
摘要
目的本研究探讨了年龄、性别、最佳矫正视力（BCVA）、驾驶能力和感知治疗效果等因素如何影响接受抗血管内皮生长因子（VEGF）注射治疗的新生血管性年龄相关性黄斑变性（nAMD）患者的生活质量（QoL）。设计基于调查的横断面研究方法我们利用接受玻璃体内抗血管内皮生长因子注射治疗的 nAMD 患者的问卷答复来评估自我报告的 QoL，并通过黄斑变性生活质量问卷进行测量。调查中的背景问题收集了患者的信息，而BCVA则来自医疗记录。我们使用二项式逻辑回归和线性回归分析了自评 QoL 与各种因素之间的关系。我们计算了粗略的几率比（OR）和 β 系数，以及根据性别、年龄和 BCVA 调整后的几率比和 β 系数。在调整后的逻辑模型中，与 QoL 高于平均水平相关的因素有男性（OR 1.65，95 % CI 1.04，2.63）、最佳视力 BCVA 超过 0.5 Snellen（OR 11.16，95 % CI 4.24，29.35）、保持驾驶能力（OR 3.35，95 % CI 1.80，6.26）和感知治疗效果（OR 2.15，95 % CI 1.07，4.34）。调整后的线性回归显示了相同的相关性，但 QoL 与生理性别之间的正相关关系在粗略模型中显著，而在调整模型中不显著（β：0.30，95 % CI -0.04，0.64）。对抗血管内皮生长因子治疗效果的看法使高 QoL 的可能性增加一倍，这突出表明有必要进一步研究其潜在的临床影响。
Factors affecting quality of life in patients with neovascular age-related macular degeneration
Purpose
This study examines how factors such as age, sex, best corrected visual acuity (BCVA), driving ability, and perceived treatment effectiveness influence quality of life (QoL) among patients with neovascular age-related macular degeneration (nAMD) in treatment with anti-vascular endothelial growth factor (VEGF) injections. Such information might be invaluable for healthcare providers, enabling them to understand who benefits from treatment.
Design
Survey-based cross-sectional study
Methods
We used questionnaire responses from patients receiving intravitreal anti-VEGF injections for nAMD to evaluate self-reported QoL, measured by the Macular Degeneration Quality of Life questionnaire. Background questions in the survey gathered patient information, while BCVA was obtained from medical records. The associations between self-rated QoL and various factors were analyzed using binomial logistic regression and linear regression. We calculated crude odds ratio (OR) and β-coefficient as well as OR and β-coefficient adjusted for sex, age, and BCVA.
Results
This study included 348 individuals, median age 79.2 years (IQR 75.0–84.0), with 58.3 % women. In the adjusted logistic model, factors associated with a QoL above average were male sex (OR 1.65, 95 % CI 1.04, 2.63), BCVA above 0.5 Snellen in best seeing eye (OR 11.16, 95 % CI 4.24, 29.35), preserved driving ability (OR 3.35, 95 % CI 1.80, 6.26), and perceiving treatment effectiveness (OR 2.15, 95 % CI 1.07, 4.34). The adjusted linear regression revealed the same associations, yet the positive relationship between QoL and biological sex was significant in the crude model but not in the adjusted model (β: 0.30, 95 % CI -0.04, 0.64).
Conclusion
Good visual acuity and driving ability strongly correlate with high QoL in patients with nAMD. Perceptions of the effectiveness of anti-VEGF treatment double the likelihood of high QoL, highlighting the need for further investigation into its potential clinical implications.
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