Zachery Quince , David Alonso-Caneiro , Scott A. Read , Damien G. Harkin , Michael J. Collins
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Ten <em>ex-vivo</em> porcine corneas were assessed and the corneal thickness was also measured to assess the impact of corneal swelling.</p></div><div><h3>Results</h3><p>An average (standard deviation) Young’s modulus of 0.271 (+/- 0.091) MPa was determined across the 10 corneas assessed. There was a mean decrease of 1.78 % in corneal thickness at the end of the compression series. These results showed that there was a moderate association between corneal thickness and the Young’s modulus recording (R<sup>2</sup> = 0.274).</p></div><div><h3>Conclusions</h3><p>Optical coherence elastography utilising clinical instrumentation, can reliably characterise the mechanical properties of the cornea. These results support the further investigation of the technique for <em>in-vivo</em> measurement of the mechanical properties of the human cornea.</p></div>","PeriodicalId":55381,"journal":{"name":"Biocybernetics and Biomedical Engineering","volume":"44 3","pages":"Pages 609-616"},"PeriodicalIF":5.3000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0208521624000597/pdfft?md5=96cdfa6e83dcdb05584641adfbe34ec8&pid=1-s2.0-S0208521624000597-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Static compression optical coherence elastography for the measurement of porcine corneal mechanical properties ex-vivo\",\"authors\":\"Zachery Quince , David Alonso-Caneiro , Scott A. Read , Damien G. Harkin , Michael J. Collins\",\"doi\":\"10.1016/j.bbe.2024.08.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Significance</h3><p>The biomechanical properties of the cornea are important for vision and ocular health. Optical coherence elastography (OCE) has the potential to improve our capacity to measure these properties.</p></div><div><h3>Aim</h3><p>This study tested a static compression OCE method utilising a commercially available optical coherence tomography (OCT) device, to estimate the Young’s modulus of <em>ex-vivo</em> porcine corneal tissue.</p><p>Approach: OCT was used to image corneal tissue samples before and during loading by static compression. The compressive force was measured with a piezoresistive force sensor, and tissue deformation was quantified through automated image analysis. Ten <em>ex-vivo</em> porcine corneas were assessed and the corneal thickness was also measured to assess the impact of corneal swelling.</p></div><div><h3>Results</h3><p>An average (standard deviation) Young’s modulus of 0.271 (+/- 0.091) MPa was determined across the 10 corneas assessed. There was a mean decrease of 1.78 % in corneal thickness at the end of the compression series. These results showed that there was a moderate association between corneal thickness and the Young’s modulus recording (R<sup>2</sup> = 0.274).</p></div><div><h3>Conclusions</h3><p>Optical coherence elastography utilising clinical instrumentation, can reliably characterise the mechanical properties of the cornea. These results support the further investigation of the technique for <em>in-vivo</em> measurement of the mechanical properties of the human cornea.</p></div>\",\"PeriodicalId\":55381,\"journal\":{\"name\":\"Biocybernetics and Biomedical Engineering\",\"volume\":\"44 3\",\"pages\":\"Pages 609-616\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0208521624000597/pdfft?md5=96cdfa6e83dcdb05584641adfbe34ec8&pid=1-s2.0-S0208521624000597-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biocybernetics and Biomedical Engineering\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0208521624000597\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biocybernetics and Biomedical Engineering","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0208521624000597","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
Static compression optical coherence elastography for the measurement of porcine corneal mechanical properties ex-vivo
Significance
The biomechanical properties of the cornea are important for vision and ocular health. Optical coherence elastography (OCE) has the potential to improve our capacity to measure these properties.
Aim
This study tested a static compression OCE method utilising a commercially available optical coherence tomography (OCT) device, to estimate the Young’s modulus of ex-vivo porcine corneal tissue.
Approach: OCT was used to image corneal tissue samples before and during loading by static compression. The compressive force was measured with a piezoresistive force sensor, and tissue deformation was quantified through automated image analysis. Ten ex-vivo porcine corneas were assessed and the corneal thickness was also measured to assess the impact of corneal swelling.
Results
An average (standard deviation) Young’s modulus of 0.271 (+/- 0.091) MPa was determined across the 10 corneas assessed. There was a mean decrease of 1.78 % in corneal thickness at the end of the compression series. These results showed that there was a moderate association between corneal thickness and the Young’s modulus recording (R2 = 0.274).
Conclusions
Optical coherence elastography utilising clinical instrumentation, can reliably characterise the mechanical properties of the cornea. These results support the further investigation of the technique for in-vivo measurement of the mechanical properties of the human cornea.
期刊介绍：
Biocybernetics and Biomedical Engineering is a quarterly journal, founded in 1981, devoted to publishing the results of original, innovative and creative research investigations in the field of Biocybernetics and biomedical engineering, which bridges mathematical, physical, chemical and engineering methods and technology to analyse physiological processes in living organisms as well as to develop methods, devices and systems used in biology and medicine, mainly in medical diagnosis, monitoring systems and therapy. The Journal''s mission is to advance scientific discovery into new or improved standards of care, and promotion a wide-ranging exchange between science and its application to humans.
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