一名韩国再生障碍性贫血患者无法预测的环孢素清除率及不良反应：病例研究。

IF 2.8 4区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Therapeutic Drug Monitoring Pub Date : 2024-08-20 DOI:10.1097/FTD.0000000000001244

Renata Shihmanter, Edward B Miller, Ekaterina Shvartsman, Haim Shmuely

引用次数: 0

摘要

摘要：一名患有慢性再生障碍性贫血的29岁韩国女性因不可预测的口服环孢素（CS）蓄积和消除时间延长而导致环孢素诱发的后可逆性脑病综合征，并出现癫痫发作。该病例表明，有必要通过谨慎调整剂量来监测环孢素的药物浓度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Unpredictable Cyclosporine Clearance in a Korean Patient with Aplastic Anemia With Adverse Effects: A Case Study.

Abstract: A 29-year-old Korean woman with chronic aplastic anemia presented with seizures due to cyclosporine-induced posterior reversible encephalopathy syndrome, caused by unpredictable oral cyclosporine (CS) accumulation and prolonged elimination. This case demonstrates the need to monitor CS drug levels with careful dose adjustments.

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来源期刊

Therapeutic Drug Monitoring 医学-毒理学

CiteScore

5.00

自引率

8.00%

发文量

213

审稿时长

4-8 weeks

期刊介绍： Therapeutic Drug Monitoring is a peer-reviewed, multidisciplinary journal directed to an audience of pharmacologists, clinical chemists, laboratorians, pharmacists, drug researchers and toxicologists. It fosters the exchange of knowledge among the various disciplines–clinical pharmacology, pathology, toxicology, analytical chemistry–that share a common interest in Therapeutic Drug Monitoring. The journal presents studies detailing the various factors that affect the rate and extent drugs are absorbed, metabolized, and excreted. Regular features include review articles on specific classes of drugs, original articles, case reports, technical notes, and continuing education articles.