现在是将认知纳入多发性硬化症进展概念的时候了，它与复发活动无关。

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY

Multiple Sclerosis Journal Pub Date : 2024-10-01 Epub Date: 2024-08-28 DOI:10.1177/13524585241264476

Stefano Ziccardi, Maddalena Guandalini, Tom A Fuchs, Massimiliano Calabrese, Ralph Hb Benedict

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引用次数: 0

摘要

最近，有人提出了多发性硬化症（MS）的独立于复发活动的进展（PIRA）模型，该模型可确定残疾的持续无声进展，而不表现出导致 MS 恶化的新的临床和磁共振成像（MRI）事件。尽管有证据表明多发性硬化症的临床表现通常会影响认知功能，而且神经心理学监测也很重要，但人们对无声的认知功能进展缺乏关注，PIRA 概念也不包括认知功能的测量。在这篇个人观点中，我们强调有必要将认知功能纳入 PIRA 模型，以便更全面地了解多发性硬化症患者的临床进展。

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The time to include cognition in the multiple sclerosis concept of progression independent from relapse activity is now.

Progression independent of relapse activity (PIRA) has been recently proposed in multiple sclerosis (MS) as a model identifying a continuous silent progression of disability without the manifestation of new clinical and magnetic resonance imaging (MRI) events that contribute to MS worsening. Despite evidence suggesting that clinical MS manifestations often affect cognitive functioning and the importance of neuropsychological monitoring over time, attention to silent cognitive progression is lacking, and the PIRA concept does not include a measure of cognitive function. In this personal viewpoint, we highlight the need to include cognition in the PIRA model to have a more comprehensive understanding of clinical progression in patients with MS.

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来源期刊

Multiple Sclerosis Journal 医学-临床神经学

CiteScore

10.90

自引率

6.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585