药物调节两种基因型小鼠的认知测试方案

IF 0.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Doklady Biochemistry and Biophysics Pub Date : 2024-08-28 DOI:10.1134/S1607672924701096

O V Perepelkina, I I Poletaeva

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引用次数: 0

摘要

成功通过 "物体永存 "测试和未通过该测试的两个品系的小鼠对注射两种药物的反应不同。注射阻断去甲肾上腺素再摄取的阿托西汀和 "非苯二氮卓 "抗焦虑药阿福巴唑的效果是不同的。被选中进行 "无解 "测试的小鼠的解题成功率提高了：而被选中进行物体永存认知测试的小鼠的解题成功率降低或效率低下。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Pharmacological Modulation of Cognitive Test Solution in Mice of Two Genotypes.

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Pharmacological Modulation of Cognitive Test Solution in Mice of Two Genotypes.

Mice of two strains selected for successful solution of "object permanence" test and for lack of such solution demonstrated the differential reaction to injections of two drugs. The effects of injections of atomoxetine. which blocks the noradrenaline reuptake, and of 'non-benzodiazepine" anxiolytic afobazol was different. The success of solutions increased in mice selected for this test "non-solution": and decreased or was inefficient in mice, selected for successful solution of object permanence cognitive test.

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来源期刊

Doklady Biochemistry and Biophysics 生物-生化与分子生物学

CiteScore

1.60

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Doklady Biochemistry and Biophysics is a journal consisting of English translations of articles published in Russian in biochemistry and biophysics sections of the Russian-language journal Doklady Akademii Nauk. The journal''s goal is to publish the most significant new research in biochemistry and biophysics carried out in Russia today or in collaboration with Russian authors. The journal accepts only articles in the Russian language that are submitted or recommended by acting Russian or foreign members of the Russian Academy of Sciences. The journal does not accept direct submissions in English.