神经激肽受体拮抗剂是治疗血管运动症状的潜在非激素疗法。

IF 2.8 3区医学 Q1 OBSTETRICS & GYNECOLOGY

Menopause: The Journal of The North American Menopause Society Pub Date : 2024-10-01 Epub Date: 2024-08-27 DOI:10.1097/GME.0000000000002414

Nanette Santoro

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引用次数: 0

摘要

对于无法或不愿接受激素治疗的女性来说，控制更年期症状是一项挑战。迄今为止，所有非激素疗法的总体疗效都不如激素疗法，而且不良反应严重，限制了它们的使用。新的科学发现了血管运动症状的根源，通过直接靶向神经激肽 3 受体及其相关通路来缓解这些令人烦恼的症状。本实践珍珠回顾了有关神经激肽受体拮抗剂的临床数据。

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Neurokinin receptor antagonists as potential nonhormone treatments for vasomotor symptoms.

Managing menopause symptoms is challenging for women unable or unwilling to take hormone therapy. All nonhormone options thus far have shown less overall efficacy compared with hormone therapy and significant adverse events that limit their use. New science has identified the source of vasomotor symptoms, achieving relief of these bothersome symptoms by directly targeting the neurokinin 3 receptor and its related pathways. This Practice Pearl reviews the clinical data available on neurokinin receptor antagonists.

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来源期刊

Menopause: The Journal of The North American Menopause Society 医学-妇产科学

CiteScore

5.40

自引率

7.40%

发文量

330

审稿时长

3-8 weeks

期刊介绍： Menopause, published monthly, provides a forum for new research, applied basic science, and clinical guidelines on all aspects of menopause. The scope and usefulness of the journal extend beyond gynecology, encompassing many varied biomedical areas, including internal medicine, family practice, medical subspecialties such as cardiology and geriatrics, epidemiology, pathology, sociology, psychology, anthropology, and pharmacology. This forum is essential to help integrate these areas, highlight needs for future research, and enhance health care.