Irina Metonidze, Nestan Bostoganashvili, Tamar Goderidze, David Tananashvili
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We divided participants into three groups according to 25(OH)D levels: group 1 = 25(OH)D <12 ng/mL (n = 83), group 2 = 25(OH)D 12-20 ng/mL (n = 141), and group 3 = 25(OH)D >20 ng/mL (n = 160).</p><p><strong>Results: </strong>The odds ratio (OR) for hospitalization in group 1 versus group 2 was 8.7 (95% confidence interval [CI] 3.6-21.3) and 5.6 for group 1 versus 3 (95% CI 2.7-11.9). Regarding oxygen therapy, OR = 28.41 for group 1 versus 2 (95% CI 3.7-220.5) and OR = 5.2 for group 1 versus 3 (95% CI 1.9-14.1). Regarding treatment with glucocorticoids, OR = 3.7 for group 1 versus 2 (95% CI 1.1-12.5) and OR = 8.4 for group 1 versus 3 (95% CI 1.8-40.7).</p><p><strong>Conclusion: </strong>COVID-19-related morbidity was associated with decreased serum 25(OH)D levels. Future studies should investigate the potential role of vitamin D sufficiency in preventing SARS-CoV-2 infection and mortality.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11350547/pdf/","citationCount":"0","resultStr":"{\"title\":\"Serum 25-hydroxyvitamin D levels and health outcomes of hospitalization owing to COVID-19: a retrospective cross-sectional study.\",\"authors\":\"Irina Metonidze, Nestan Bostoganashvili, Tamar Goderidze, David Tananashvili\",\"doi\":\"10.1177/03000605241271770\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>We investigated the role of serum 25(OH)D (25-hydroxyvitamin D) in COVID-related health outcomes.</p><p><strong>Methods: </strong>We conducted a retrospective cross-sectional study using data of the National Center of Disease Control and Public Health, Georgia. We extracted patient data including length of hospital stay, transfer to the intensive care unit, requirement for oxygen therapy, treatment with glucocorticoids, and symptoms. After obtaining written informed consent, 384 individuals were enrolled. We divided participants into three groups according to 25(OH)D levels: group 1 = 25(OH)D <12 ng/mL (n = 83), group 2 = 25(OH)D 12-20 ng/mL (n = 141), and group 3 = 25(OH)D >20 ng/mL (n = 160).</p><p><strong>Results: </strong>The odds ratio (OR) for hospitalization in group 1 versus group 2 was 8.7 (95% confidence interval [CI] 3.6-21.3) and 5.6 for group 1 versus 3 (95% CI 2.7-11.9). Regarding oxygen therapy, OR = 28.41 for group 1 versus 2 (95% CI 3.7-220.5) and OR = 5.2 for group 1 versus 3 (95% CI 1.9-14.1). 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引用次数: 0
摘要
目的我们研究了血清 25(OH)D（25-羟基维生素 D）在 COVID 相关健康结果中的作用：我们利用格鲁吉亚国家疾病控制和公共卫生中心的数据进行了一项回顾性横断面研究。我们提取了患者的数据，包括住院时间、转入重症监护室、氧疗需求、糖皮质激素治疗和症状。在获得书面知情同意后，384 人加入了研究。我们根据25（OH）D水平将参与者分为三组：第一组=25（OH）D 20纳克/毫升（n = 160）：结果：第 1 组与第 2 组相比，住院治疗的几率比（OR）为 8.7（95% 置信区间 [CI] 3.6-21.3），第 1 组与第 3 组相比，住院治疗的几率比（OR）为 5.6（95% 置信区间 [CI] 2.7-11.9）。在氧疗方面，1 组与 2 组的 OR = 28.41（95% CI 3.7-220.5），1 组与 3 组的 OR = 5.2（95% CI 1.9-14.1）。在使用糖皮质激素治疗方面，1组与2组的OR=3.7（95% CI 1.1-12.5），1组与3组的OR=8.4（95% CI 1.8-40.7）：结论：COVID-19相关发病率与血清25（OH）D水平下降有关。结论：与 COVID-19 相关的发病率与血清 25（OH）D 水平下降有关。未来的研究应探讨维生素 D 不足在预防 SARS-CoV-2 感染和死亡率方面的潜在作用。
Serum 25-hydroxyvitamin D levels and health outcomes of hospitalization owing to COVID-19: a retrospective cross-sectional study.
Objective: We investigated the role of serum 25(OH)D (25-hydroxyvitamin D) in COVID-related health outcomes.
Methods: We conducted a retrospective cross-sectional study using data of the National Center of Disease Control and Public Health, Georgia. We extracted patient data including length of hospital stay, transfer to the intensive care unit, requirement for oxygen therapy, treatment with glucocorticoids, and symptoms. After obtaining written informed consent, 384 individuals were enrolled. We divided participants into three groups according to 25(OH)D levels: group 1 = 25(OH)D <12 ng/mL (n = 83), group 2 = 25(OH)D 12-20 ng/mL (n = 141), and group 3 = 25(OH)D >20 ng/mL (n = 160).
Results: The odds ratio (OR) for hospitalization in group 1 versus group 2 was 8.7 (95% confidence interval [CI] 3.6-21.3) and 5.6 for group 1 versus 3 (95% CI 2.7-11.9). Regarding oxygen therapy, OR = 28.41 for group 1 versus 2 (95% CI 3.7-220.5) and OR = 5.2 for group 1 versus 3 (95% CI 1.9-14.1). Regarding treatment with glucocorticoids, OR = 3.7 for group 1 versus 2 (95% CI 1.1-12.5) and OR = 8.4 for group 1 versus 3 (95% CI 1.8-40.7).
Conclusion: COVID-19-related morbidity was associated with decreased serum 25(OH)D levels. Future studies should investigate the potential role of vitamin D sufficiency in preventing SARS-CoV-2 infection and mortality.
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