了解系统性硬化症中的胃肠道微生物组:方法学进展和新兴研究。

IF 5.2 2区 医学 Q1 RHEUMATOLOGY
Alana J Haussmann, Zsuzsanna H McMahan, Elizabeth R Volkmann
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引用次数: 0

摘要

综述的目的:本综述强调了胃肠道微生物组在系统性硬化症(SSc)中的作用。我们介绍了评估人体胃肠道微生物组的技术,以及将胃肠道微生物组改变(即菌群失调)与不同的系统性硬化症临床表现联系起来的新兴研究。我们还讨论了针对 SSc 中菌群失调的不断发展的治疗方法:最近的文献聚焦于消化道微生物组与 SSc 发病机制之间的复杂关系。先进的技术(如霰粒元基因组学、元转录组学)使人们对微生物分类和活性基因表达有了更深入的了解,暴露出菌群失调是导致 SSc 的潜在因素。新研究表明,具有特定 SSc 临床特征(如间质性肺病)的 SSc 患者具有独特的消化道微生物组特征。研究消化道微生物组的新工具进一步加深了我们对菌群失调与 SSc 并发症之间关系的理解。饮食调整、益生菌、抗生素、正念练习和粪便移植等治疗途径为通过调节消化道微生物组来控制 SSc 和防止其恶化提供了可能。本综述通过阐明消化道菌群失调、消化道功能障碍和 SSc 之间的关系,加深了我们对 SSc 发病机制的了解,并提出了有针对性的干预措施。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Understanding the gastrointestinal microbiome in systemic sclerosis: methodological advancements and emerging research.

Purpose of review: This review highlights the role of the gastrointestinal (GI) microbiome in systemic sclerosis (SSc). We describe techniques for evaluating the GI microbiome in humans, and emerging research linking GI microbiome alterations (i.e., dysbiosis) and distinct SSc clinical manifestations. We also address the evolving treatment landscape targeting dysbiosis in SSc.

Recent findings: Recent literature brings into focus the complex relationship between the GI microbiome and SSc pathogenesis. Advanced techniques (e.g., shotgun metagenomics, meta-transcriptomics) provide deeper insights into microbial taxonomy and active gene expression, exposing dysbiosis as a potential driver of SSc. New studies demonstrate that SSc patients who possess specific SSc clinical features, (e.g., interstitial lung disease), have unique GI microbiome profiles.

Summary: Dysbiosis is associated with specific clinical features in patients with SSc. New tools for studying the GI microbiome have furthered our understanding of the relationship between dysbiosis and SSc complications. Therapeutic avenues such as dietary adjustments, probiotics, antibiotics, mindfulness practices, and fecal transplants offer potential for managing SSc and preventing its progression through GI microbiome modulation. By clarifying what is known about the relationship between the GI dysbiosis, GI dysfunction, and SSc, this review enhances our understanding of SSc pathogenesis and proposes targeted interventions.

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来源期刊
Current opinion in rheumatology
Current opinion in rheumatology 医学-风湿病学
CiteScore
9.70
自引率
2.00%
发文量
89
审稿时长
6-12 weeks
期刊介绍: A high impact review journal which boasts an international readership, Current Opinion in Rheumatology offers a broad-based perspective on the most recent and exciting developments within the field of rheumatology. Published bimonthly, each issue features insightful editorials and high quality invited reviews covering two or three key disciplines which include vasculitis syndromes, medical physiology and rheumatic diseases, crystal deposition diseases and rheumatoid arthritis. Each discipline introduces world renowned guest editors to ensure the journal is at the forefront of knowledge development and delivers balanced, expert assessments of advances from the previous year.
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