利用植物化学物质在神经母细胞瘤中的治疗潜力。

IF 5 3区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
BioFactors Pub Date : 2024-08-27 DOI:10.1002/biof.2115
Seyed Sajad Ahmadi, Omid Bagherzadeh, Meysam Sargazi, Farnaz Kalantar, Mohammad Amin Elahi Najafi, Mohammad Mahdi Vahedi, Amir R Afshari, Amirhossein Sahebkar
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引用次数: 0

摘要

神经母细胞瘤是脑外最常见的实体瘤,起源于未成熟的神经嵴细胞,约占所有儿科恶性肿瘤的10%。神经母细胞瘤的治疗采用多模式疗法,包括手术、放疗、化疗和免疫疗法。所有这些方法都受到副作用的限制,副作用可能很严重,预后差,复发风险高。在寻求其他治疗方法的过程中,植物化学物质因其抗肿瘤特性、安全性和多机制作用模式而备受关注。有几项研究使用了植物提取的生物活性化合物,如酚类和类黄酮,这表明它们能调节神经母细胞瘤所涉及的生物分子和信号转导途径。我们回顾了近期证明植物化学物质对神经母细胞瘤影响的临床前和临床研究结果,揭示了其分子作用机制和潜在的治疗应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Harnessing the therapeutic potential of phytochemicals in neuroblastoma.

Harnessing the therapeutic potential of phytochemicals in neuroblastoma.

Neuroblastomas are the most common solid tumors outside of the brain that originate from immature neural crest cells, accounting for about 10% of all pediatric malignancies. The treatment for neuroblastomas involves a multimodal schedule, including surgery, radiation, chemotherapy, and immunotherapy. All these modalities are limited by side effects that might be severe, poor prognosis, and a high risk of recurrence. In the quest for additional therapeutic approaches, phytochemicals have attracted attention owing to their reported antitumor properties, safety, and multimechanistic mode of action. Several studies have used plant-derived bioactive compounds such as phenolics and flavonoids, suggesting modulation of biomolecules and signal transduction pathways involved in neuroblastoma. We reviewed the findings of recent preclinical and clinical studies demonstrating the effects of phytochemicals on neuroblastoma, shedding light on their molecular mechanism of action and potential therapeutic applications.

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来源期刊
BioFactors
BioFactors 生物-内分泌学与代谢
CiteScore
11.50
自引率
3.30%
发文量
96
审稿时长
6-12 weeks
期刊介绍: BioFactors, a journal of the International Union of Biochemistry and Molecular Biology, is devoted to the rapid publication of highly significant original research articles and reviews in experimental biology in health and disease. The word “biofactors” refers to the many compounds that regulate biological functions. Biological factors comprise many molecules produced or modified by living organisms, and present in many essential systems like the blood, the nervous or immunological systems. A non-exhaustive list of biological factors includes neurotransmitters, cytokines, chemokines, hormones, coagulation factors, transcription factors, signaling molecules, receptor ligands and many more. In the group of biofactors we can accommodate several classical molecules not synthetized in the body such as vitamins, micronutrients or essential trace elements. In keeping with this unified view of biochemistry, BioFactors publishes research dealing with the identification of new substances and the elucidation of their functions at the biophysical, biochemical, cellular and human level as well as studies revealing novel functions of already known biofactors. The journal encourages the submission of studies that use biochemistry, biophysics, cell and molecular biology and/or cell signaling approaches.
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