用于检测疾病生物标记物的肽基电化学生物传感器

IF 10.61 Q3 Biochemistry, Genetics and Molecular Biology
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引用次数: 0

摘要

要了解蛋白质、核酸、抗体、酶、病毒和循环肿瘤细胞等临床上重要的疾病特异性生物标记物在疾病诊断和预后中的作用,就必须对其进行检测。因此,目前的临床研究旨在开发一种生物传感器,用于超灵敏、可靠和特异性地检测体液(包括尿液、唾液和血液)中这些低含量的生物分子。电化学生物传感器是一种功能强大的设备,可在临床诊断中简单、快速、经济地检测疾病生物标志物。肽是一组令人感兴趣的生物识别元素的缩影,由于其稳定性和对目标分析物的选择性,可与电化学传感器相连接。此外,肽类物质易于合成,并可通过指定的功能基团进行修饰,因此适合用于创建电化学生物传感系统的创新架构。在这篇综述中,我们概述了在材料设计、识别系统以及与制造用于疾病生物标记物检测的肽基电化学生物传感器相关的策略进展方面的最新进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Peptide-based electrochemical biosensors for the detection of disease biomarkers

The detection of clinically important disease-specific biomarkers such as proteins, nucleic acids, antibodies, enzymes, viruses and circulating tumor cells is essential for understanding their role in disease diagnosis and prognosis. Thus, current clinical research aims at developing a biosensor for the ultrasensitive, reliable, and specific detection of these low-abundant biomolecules in bodily fluids including urine, saliva, and blood. Electrochemical biosensors are powerful devices that make it simple, quick, and affordable the detection of disease biomarkers in clinical diagnostics Peptides epitomize an intriguing group of biorecognition elements that can be linked to electrochemical transducers owing to their stability and selectivity concerning a target analyte. Moreover, they are amenable to facile synthesis and modification with designated functional groups, rendering them appropriate for the creation of innovative architectures for electrochemical biosensing systems. In this review, we provided an outline of the most recent developments in material designs, recognition systems, and strategy advancements related to fabricating peptide-based electrochemical biosensors for disease biomarker detection.

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来源期刊
Biosensors and Bioelectronics: X
Biosensors and Bioelectronics: X Biochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
4.60
自引率
0.00%
发文量
166
审稿时长
54 days
期刊介绍: Biosensors and Bioelectronics: X, an open-access companion journal of Biosensors and Bioelectronics, boasts a 2020 Impact Factor of 10.61 (Journal Citation Reports, Clarivate Analytics 2021). Offering authors the opportunity to share their innovative work freely and globally, Biosensors and Bioelectronics: X aims to be a timely and permanent source of information. The journal publishes original research papers, review articles, communications, editorial highlights, perspectives, opinions, and commentaries at the intersection of technological advancements and high-impact applications. Manuscripts submitted to Biosensors and Bioelectronics: X are assessed based on originality and innovation in technology development or applications, aligning with the journal's goal to cater to a broad audience interested in this dynamic field.
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