在泌尿生殖系统癌症治疗过程中应用精准医疗的障碍和促进因素：来自撒哈拉以南非洲中低收入国家的视角。

IF 2.4 3区医学 Q3 ONCOLOGY

Urologic Oncology-seminars and Original Investigations Pub Date : 2024-08-24 DOI:10.1016/j.urolonc.2024.07.014

Musliu Adetola Tolani F.W.A.C.S. , Ismail Hadi Zubairu F.W.A.C.S. , Kabir Balarabe F.M.C.S. , Mudi Awaisu F.W.A.C.S. , Mubarak Abdullahi F.W.A.C.S. , Adeoluwa Akeem Adeniji F.W.A.C.S. , Shehu Salihu Umar F.W.A.C.S. , Ahmad Bello F.W.A.C.S. , Scott T. Tagawa M.D.

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引用次数: 0

摘要

全球肿瘤学界日益认识到，在正确的时间为正确的患者提供正确的癌症治疗方式的益处。尼日利亚是非洲人口最多的国家，但有关精准肿瘤学在泌尿生殖系统癌症治疗中的作用和可行潜力的信息却很有限。因此，本文介绍了个性化医疗在尼日利亚的应用现状及其障碍和促进因素。文章详细介绍了人力分布和流行病学差异。文章还探讨了临床和生物标记物在筛查和早期诊断中的应用、团队科学在支持基因组剖析中的应用、基于图像表型的精准肿瘤学的成本效益方法、分子成像的新兴作用、获得临床试验的机会；以及它们在支持数据驱动的诊断、治疗决策和护理可用性方面的潜力，以弥补该国在泌尿生殖系统癌症管理方面的差距。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Barriers and facilitators of the application of precision medicine to the genitourinary cancer care pathway: Perspective from a low- and middle- income country in sub-Saharan Africa

The benefit of the delivery of the right form of cancer care, tailored to the right patient, at the right time is increasingly being recognized in the global oncology community. Information on the role and feasible potential of precision oncology during the management of genitourinary cancer in Nigeria, the most populous country in Africa, is limited. This article, therefore, describes the present application of personalized medicine in Nigeria and its barriers and facilitators. It provided granular details on manpower distribution and epidemiological disparities. It also explored the use of clinical and biological markers for screening and early diagnosis, the application of team science to support genomic profiling, cost-effective approaches for image-based phenotypic precision oncology, the emerging role of molecular imaging, access to clinical trials; and their potential to support data driven diagnosis, treatment decision and care availability in order to address gaps in genitourinary cancer management in the country.

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来源期刊

Urologic Oncology-seminars and Original Investigations 医学-泌尿学与肾脏学

CiteScore

4.80

自引率

3.70%

发文量

297

审稿时长

7.6 weeks

期刊介绍： Urologic Oncology: Seminars and Original Investigations is the official journal of the Society of Urologic Oncology. The journal publishes practical, timely, and relevant clinical and basic science research articles which address any aspect of urologic oncology. Each issue comprises original research, news and topics, survey articles providing short commentaries on other important articles in the urologic oncology literature, and reviews including an in-depth Seminar examining a specific clinical dilemma. The journal periodically publishes supplement issues devoted to areas of current interest to the urologic oncology community. Articles published are of interest to researchers and the clinicians involved in the practice of urologic oncology including urologists, oncologists, and radiologists.