Anshu Sharma, Yea Rock Park, Aman Garg, Bong-Seop Lee
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引用次数: 0
摘要
深共晶溶剂（DES）是一种环保型溶剂，具有溶解生物活性化合物而不影响其特性的潜力。DES 具有特殊的品质，可根据各种治疗需求定制，以满足生物大分子/活性药物成分 (API) 的独特特性，通过解决制药学中的溶解性问题，为创造尖端药物制剂提供了可靠的方法。本研究概述了新开发的方法，以解决因溶解性差而导致的原料药提取效率低下的问题。这些新策略还能改变原料药的化学和物理稳定性，从而延长药物的保质期并提高其对健康的益处。预计重点介绍的方法和工艺将得到开发，以充分利用 DES 的潜力，改善制药行业的药物溶解度和输送。
Deep Eutectic Solvents Enhancing Drug Solubility and Its Delivery.
Deep eutectic solvents (DES) are environmentally friendly solvents with the potential to dissolve bioactive compounds without affecting their characteristics. DES has special qualities that can be customized to meet the unique characteristics of a biomolecule/active pharmaceutical ingredient (API) in accordance with various therapeutic needs, providing a reliable approach in opening the door for the creation of cutting-edge drug formulations by resolving solubility issues in pharmaceutics. This study outlines newly developing approaches to solve the problem of inefficient API extraction due to poor solubility. These emerging strategies also have the capacity to alter the chemical and physical stability of API, which triggers drug's shelf life and their possible health benefits. It is anticipated that the highlighted methods and processes will be developed to capitalize on the DES potential to improve drug solubility and delivery in the pharmaceutical sector.
期刊介绍：
The Journal of Medicinal Chemistry is a prestigious biweekly peer-reviewed publication that focuses on the multifaceted field of medicinal chemistry. Since its inception in 1959 as the Journal of Medicinal and Pharmaceutical Chemistry, it has evolved to become a cornerstone in the dissemination of research findings related to the design, synthesis, and development of therapeutic agents.
The Journal of Medicinal Chemistry is recognized for its significant impact in the scientific community, as evidenced by its 2022 impact factor of 7.3. This metric reflects the journal's influence and the importance of its content in shaping the future of drug discovery and development. The journal serves as a vital resource for chemists, pharmacologists, and other researchers interested in the molecular mechanisms of drug action and the optimization of therapeutic compounds.
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