Arife Akay, Yıldız Akdaş Reis, Büşra Şahin, Asya Kalaycı Öncü, Mehmet Obut, Cantekin İskender, Şevki Çelen
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Demographic characteristics, obstetric histories, ultrasonographic findings, and free β-hCG and PAPP-A levels of the groups were compared.</p><p><strong>Results: </strong>There were 119 cases in the study group and 153 cases in the control group. The median vertical and longitudinal lengths of the SH were 31 mm and 16 mm. The median age of both groups was similar (p=0.422). The MoM value of PAPP-A was 0.088 (.93) in the study group and 0.9 (0.63) in the control group (p=0.519). Similarly, the MoM value of free β-hCG was 1.04 (0.78) in the study group and 0.99 (0.86) in the control group (p=0.66). No significant relationship was found in the multivariate analysis between free β-hCG MoM, PAPP-A MoM, age, gravida, and vertical and longitudinal lengths of the hematoma (p>0.05).</p><p><strong>Conclusion: </strong>The level of PAPP-A and free β-hCG were not affected by the SH. Therefore, these markers can be used reliably in TM cases with SH for the first-trimester fetal aneuploidy screening test.</p>","PeriodicalId":74699,"journal":{"name":"Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia","volume":"46 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11341181/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effect of subchorionic hematoma on first-trimester maternal serum free β-hCG and PAPP-A levels.\",\"authors\":\"Arife Akay, Yıldız Akdaş Reis, Büşra Şahin, Asya Kalaycı Öncü, Mehmet Obut, Cantekin İskender, Şevki Çelen\",\"doi\":\"10.61622/rbgo/2024rbgo66\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study aimed to investigate the effects of the presence of subchorionic hematoma (SH) in early pregnancies with threatened miscarriage (TM) on levels of first-trimester maternal serum markers, pregnancy-associated plasma protein-A (PAPP-A), and free β-human chorionic gonadotropin (β-hCG) levels.</p><p><strong>Methods: </strong>The data of TM cases with SH in the first trimester between 2015 and 2021 were evaluated retrospectively. The data of age and gestational age-matched TM cases without SH were also assessed to constitute a control group. Demographic characteristics, obstetric histories, ultrasonographic findings, and free β-hCG and PAPP-A levels of the groups were compared.</p><p><strong>Results: </strong>There were 119 cases in the study group and 153 cases in the control group. The median vertical and longitudinal lengths of the SH were 31 mm and 16 mm. The median age of both groups was similar (p=0.422). The MoM value of PAPP-A was 0.088 (.93) in the study group and 0.9 (0.63) in the control group (p=0.519). Similarly, the MoM value of free β-hCG was 1.04 (0.78) in the study group and 0.99 (0.86) in the control group (p=0.66). No significant relationship was found in the multivariate analysis between free β-hCG MoM, PAPP-A MoM, age, gravida, and vertical and longitudinal lengths of the hematoma (p>0.05).</p><p><strong>Conclusion: </strong>The level of PAPP-A and free β-hCG were not affected by the SH. 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引用次数: 0
摘要
研究目的本研究旨在探讨妊娠早期出现绒毛膜下血肿（SH）对第一胎母体血清标志物、妊娠相关血浆蛋白-A（PAPP-A）和游离β-人绒毛膜促性腺激素（β-hCG）水平的影响：方法：回顾性评估了 2015 年至 2021 年间妊娠头三个月出现 SH 的 TM 病例数据。同时还评估了年龄和胎龄匹配的无 SH TM 病例的数据，作为对照组。比较了两组的人口统计学特征、产科病史、超声波检查结果、游离β-hCG和PAPP-A水平：研究组 119 例，对照组 153 例。SH的纵向和纵向中位长度分别为31毫米和16毫米。两组的中位年龄相似（P=0.422）。研究组 PAPP-A 的 MoM 值为 0.088（0.93），对照组为 0.9（0.63）（P=0.519）。同样，研究组游离β-hCG的MoM值为1.04（0.78），对照组为0.99（0.86）（P=0.66）。在多变量分析中，游离β-hCG MoM、PAPP-A MoM、年龄、孕酮、血肿的纵向和纵向长度之间均无明显关系（P>0.05）：结论：PAPP-A 和游离β-hCG 的水平不受 SH 的影响。结论：PAPP-A和游离β-hCG的水平不受SH的影响，因此这些标记物可可靠地用于TM伴SH病例的首胎胎儿非整倍体筛查试验。
Effect of subchorionic hematoma on first-trimester maternal serum free β-hCG and PAPP-A levels.
Objective: This study aimed to investigate the effects of the presence of subchorionic hematoma (SH) in early pregnancies with threatened miscarriage (TM) on levels of first-trimester maternal serum markers, pregnancy-associated plasma protein-A (PAPP-A), and free β-human chorionic gonadotropin (β-hCG) levels.
Methods: The data of TM cases with SH in the first trimester between 2015 and 2021 were evaluated retrospectively. The data of age and gestational age-matched TM cases without SH were also assessed to constitute a control group. Demographic characteristics, obstetric histories, ultrasonographic findings, and free β-hCG and PAPP-A levels of the groups were compared.
Results: There were 119 cases in the study group and 153 cases in the control group. The median vertical and longitudinal lengths of the SH were 31 mm and 16 mm. The median age of both groups was similar (p=0.422). The MoM value of PAPP-A was 0.088 (.93) in the study group and 0.9 (0.63) in the control group (p=0.519). Similarly, the MoM value of free β-hCG was 1.04 (0.78) in the study group and 0.99 (0.86) in the control group (p=0.66). No significant relationship was found in the multivariate analysis between free β-hCG MoM, PAPP-A MoM, age, gravida, and vertical and longitudinal lengths of the hematoma (p>0.05).
Conclusion: The level of PAPP-A and free β-hCG were not affected by the SH. Therefore, these markers can be used reliably in TM cases with SH for the first-trimester fetal aneuploidy screening test.
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