[男性生殖系统疾病中的铁变态反应：研究进展]。

Q4 Medicine

中华男科学杂志 Pub Date : 2024-02-01

A-Jian Peng, Xue Tang, Gu-Fen Jiang, Xing Zhou

{"title":"[男性生殖系统疾病中的铁变态反应：研究进展]。","authors":"A-Jian Peng, Xue Tang, Gu-Fen Jiang, Xing Zhou","doi":"","DOIUrl":null,"url":null,"abstract":"Ferroptosis is an iron-dependent form of programmed cell death triggered by the excessive accumulation of lipid peroxides on the cell membrane. Recent studies have found that ferroptosis can be induced by exposure of the testis tissue and germ cells to some high-risk factors, accompanied by various characteristic reproductive system injuries, including changes in cell morphology, ferroptosis-related physicochemical indicators and gene expressions. This review focuses on the association of ferroptosis with male reproductive system diseases from three key aspects: iron metabolism abnormalities, Cystine/GSH/GPX4 axis imbalance, and lipid peroxidation.","PeriodicalId":24012,"journal":{"name":"中华男科学杂志","volume":"30 2","pages":"174-179"},"PeriodicalIF":0.0000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Ferroptosis in male reproductive system diseases: Progress in research].\",\"authors\":\"A-Jian Peng, Xue Tang, Gu-Fen Jiang, Xing Zhou\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Ferroptosis is an iron-dependent form of programmed cell death triggered by the excessive accumulation of lipid peroxides on the cell membrane. Recent studies have found that ferroptosis can be induced by exposure of the testis tissue and germ cells to some high-risk factors, accompanied by various characteristic reproductive system injuries, including changes in cell morphology, ferroptosis-related physicochemical indicators and gene expressions. This review focuses on the association of ferroptosis with male reproductive system diseases from three key aspects: iron metabolism abnormalities, Cystine/GSH/GPX4 axis imbalance, and lipid peroxidation.\",\"PeriodicalId\":24012,\"journal\":{\"name\":\"中华男科学杂志\",\"volume\":\"30 2\",\"pages\":\"174-179\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中华男科学杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华男科学杂志","FirstCategoryId":"3","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

摘要

铁中毒是一种铁依赖性的细胞程序性死亡，由细胞膜上脂质过氧化物的过度积累引发。最近的研究发现，睾丸组织和生殖细胞暴露于某些高危因素下可诱发铁中毒，并伴有各种特征性生殖系统损伤，包括细胞形态、铁中毒相关理化指标和基因表达的变化。本综述主要从铁代谢异常、胱氨酸/GSH/GPX4 轴失衡和脂质过氧化三个方面探讨铁中毒与男性生殖系统疾病的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

[Ferroptosis in male reproductive system diseases: Progress in research].

Ferroptosis is an iron-dependent form of programmed cell death triggered by the excessive accumulation of lipid peroxides on the cell membrane. Recent studies have found that ferroptosis can be induced by exposure of the testis tissue and germ cells to some high-risk factors, accompanied by various characteristic reproductive system injuries, including changes in cell morphology, ferroptosis-related physicochemical indicators and gene expressions. This review focuses on the association of ferroptosis with male reproductive system diseases from three key aspects: iron metabolism abnormalities, Cystine/GSH/GPX4 axis imbalance, and lipid peroxidation.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

中华男科学杂志 Medicine-Medicine (all)

CiteScore

0.40

自引率

0.00%

发文量

5367

期刊介绍： National journal of andrology was founded in June 1995. It is a core journal of andrology and reproductive medicine, published monthly, and is publicly distributed at home and abroad. The main columns include expert talks, monographs (basic research, clinical research, evidence-based medicine, traditional Chinese medicine), reviews, clinical experience exchanges, case reports, etc. Priority is given to various fund-funded projects, especially the 12th Five-Year National Support Plan and the National Natural Science Foundation funded projects. This journal is included in about 20 domestic databases, including the National Science and Technology Paper Statistical Source Journal (China Science and Technology Core Journal), the Source Journal of the China Science Citation Database, the Statistical Source Journal of the China Academic Journal Comprehensive Evaluation Database (CAJCED), the Full-text Collection Journal of the China Journal Full-text Database (CJFD), the Overview of the Chinese Core Journals (2017 Edition), and the Source Journal of the Top Academic Papers of China's Fine Science and Technology Journals (F5000). It has been included in the full text of the American Chemical Abstracts, the American MEDLINE, the American EBSCO, and the database.