埃勒斯-丹洛斯综合征患者早期乳腺癌的手术和放射治疗病例。

IF 0.7 Q4 SURGERY
Asumi Yamazaki, Hiroshi Tada, Yuki Muroyama, Yuto Yamazaki, Minoru Miyashita, Narumi Harada-Shoji, Yohei Hamanaka, Akiko Ebata, Miku Sato, Tokiwa Motonari, Mika Yanagaki, Tomomi Kon, Aru Sakamoto, Takashi Suzuki, Takanori Ishida
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引用次数: 0

摘要

背景:埃勒斯-丹洛斯综合征(EDS)是一种罕见的遗传性结缔组织疾病,其特点是皮肤和关节过度伸展,皮肤和血管组织脆弱。目前还没有关于血管性 EDS 患者患乳腺癌的报道。在此,我们报告了一例非常罕见的血管性 EDS 患者患乳腺癌的病例:一名患有血管性 EDS 的 46 岁女性因体检发现左侧乳腺癌(c 阶段 0)而接受了左侧乳房部分切除术和前哨淋巴结活检。最终病理诊断为乳腺浸润性导管癌(p 阶段 IA)[激素受体阳性,HER2 评分 2 等(FISH 阳性),Ki-67LI 18%,腔隙-HER2 型]。提交 BluePrint 是为了帮助确定术后治疗策略,BluePrint 分子亚型 HER2-类型。然而,使用 Predict 预测的 10 年乳腺癌死亡风险较低(5%)。与患者协商后,决定术后只对保留的乳房进行放射治疗,同时使用激素治疗。术后伤口愈合没有延迟,患者术后 9 个月没有转移复发:我们为一名患有血管性 EDS 的乳腺癌患者实施了手术、术后放疗和激素治疗,未出现重大并发症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Surgical and irradiated case of early breast cancer in a patient with Ehlers-Danlos syndrome.

Background: Ehlers-Danlos syndrome (EDS) is a rare inherited connective tissue disease characterized by hyperextensibility of the skin and joints and tissue fragility of the skin and blood vessels, Vascular EDS is the most severe form of EDS, with abnormal arterial fragility. There have been no reports of breast cancer occurring in patients with vascular EDS. Here, we report here a very rare case of breast cancer in a patient with vascular EDS.

Case presentation: A 46-year-old woman with vascular EDS underwent partial left mastectomy and sentinel lymph node biopsy for left breast cancer (cStage 0) detected by medical examination. The final pathological diagnosis was invasive ductal carcinoma of the breast (pStage IA) [hormone receptor-positive, HER2 score 2 equivocal (FISH-positive), Ki-67LI 18%, luminal-HER2 type]. BluePrint was submitted as an aid in determining the postoperative treatment strategy, BluePrint Molecular Subtype HER2-type. However, the 10-year breast cancer mortality risk using Predict was low (5%). After consultation with the patient, the decision was made to administer postoperative radiation to the preserved breast along with hormone therapy only. There was no delay in postoperative wound healing, and the patient was free of metastatic recurrence for 9 months after surgery.

Conclusion: We performed surgery, postoperative radiotherapy, and hormonal therapy in a breast cancer patient with vascular EDS without major complications.

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