细胞外囊泡在代谢损伤和 2 型糖尿病发病机制中的相互作用。

IF 6.1 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2024-08-21 DOI:10.1016/j.diabres.2024.111837

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引用次数: 0

摘要

2 型糖尿病（T2D）的发病机制涉及多个器官的功能障碍，包括肝脏、肌肉、脂肪组织和胰腺，从而导致胰岛素抵抗和 β 细胞衰竭。最近的研究强调了细胞外囊泡 (EVs) 在 T2D 中介导器官间沟通的重要作用。本综述探讨了 EVs 的作用，重点是它们在受 T2D 影响的人体血浆和组织中的存在及其生物学意义。我们探讨了影响胰岛素信号传导和葡萄糖代谢的特定 EV 载体，如 miRNA 和蛋白质，强调了它们作为生物标记物的潜力。通过强调 EVs 在诊断和治疗方面的潜力，我们希望就 EVs 在 T2D 早期检测、疾病监测和创新治疗策略方面的作用提供新的见解。

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The interplay of extracellular vesicles in the pathogenesis of metabolic impairment and type 2 diabetes

The pathogenesis of type 2 diabetes (T2D) involves dysfunction in multiple organs, including the liver, muscle, adipose tissue, and pancreas, leading to insulin resistance and β cell failure. Recent studies highlight the significant role of extracellular vesicles (EVs) in mediating inter-organ communication in T2D. This review investigates the role of EVs, focusing on their presence and biological significance in human plasma and tissues affected by T2D. We explore specific EV cargo, such as miRNAs and proteins, which affect insulin signaling and glucose metabolism, emphasizing their potential as biomarkers. By highlighting the diagnostic and therapeutic potential of EVs, we aim to provide new insights into their role in early detection, disease monitoring, and innovative treatment strategies for T2D.

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.