Yuanci Zhang, Songtao Ji, Ge Miao, Shuya Du, Haojia Wang, Xiaohua Yang, Ang Li, Yuanyuan Lu, Xin Wang, Xiaodi Zhao
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引用次数: 0
摘要
结肠直肠癌(CRC)是全球第三大常见癌症,也是导致癌症相关死亡的第二大原因。树突状细胞(DC)是一组异质性的抗原递呈细胞,对于启动和调节先天性和适应性免疫反应非常重要。作为免疫系统的重要组成部分,树突状细胞在 CRC 的发病机制和临床治疗中起着举足轻重的作用。DCs交叉呈现肿瘤相关抗原,激活T细胞,引发抗肿瘤免疫反应。然而,由于肿瘤微环境的存在,DCs 的抗肿瘤免疫功能会受到损害,并促进免疫耐受。这篇综述系统地阐明了不同 DC 亚群的具体特征和功能,以及 DC 在 CRC 微环境中的免疫应答和耐受中发挥的作用。此外,还讨论了直流电如何促进 CRC 的进展以及在现有数据基础上增强抗肿瘤免疫力的潜在疗法,这将为 CRC 患者的免疫疗法提供新的视角和方法。
The current role of dendritic cells in the progression and treatment of colorectal cancer.
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related deaths worldwide. Dendritic cells (DCs) constitute a heterogeneous group of antigen-presenting cells that are important for initiating and regulating both innate and adaptive immune responses. As a crucial component of the immune system, DCs have a pivotal role in the pathogenesis and clinical treatment of CRC. DCs cross-present tumor-related antigens to activate T cells and trigger an antitumor immune response. However, the antitumor immune function of DCs is impaired and immune tolerance is promoted due to the presence of the tumor microenvironment. This review systematically elucidates the specific characteristics and functions of different DC subsets, as well as the role that DCs play in the immune response and tolerance within the CRC microenvironment. Moreover, how DCs contribute to the progression of CRC and potential therapies to enhance antitumor immunity on the basis of existing data are also discussed, which will provide new perspectives and approaches for immunotherapy in patients with CRC.
期刊介绍:
Cancer Biology & Medicine (ISSN 2095-3941) is a peer-reviewed open-access journal of Chinese Anti-cancer Association (CACA), which is the leading professional society of oncology in China. The journal quarterly provides innovative and significant information on biological basis of cancer, cancer microenvironment, translational cancer research, and all aspects of clinical cancer research. The journal also publishes significant perspectives on indigenous cancer types in China.