炎症性肠病中的降钙素原：诊断或预后标志物

IF 2.9 4区医学 Q2 PATHOLOGY

Pathology, research and practice Pub Date : 2024-08-15 DOI:10.1016/j.prp.2024.155548

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引用次数: 0

摘要

血清学生物标志物作为早期检测炎症性肠病（IBD）的非侵入性检测方法，发展迅速。降钙素原（PCT）是一种新型急性期反应蛋白，在炎症过程中，尤其是细菌感染时会升高。本研究旨在回顾前降钙素原在 IBD 活动中的诊断价值。然而，关于 PCT 在检测 IBD 疾病活动性中的作用存在争议。研究显示了不同的诊断切点（从 0.13 到 1.0 ng/dl）和最高达 93 % 的灵敏度。虽然在确定疾病活动性方面，PCT 作为一种有价值的诊断标志物的作用尚未明确，但在测量其他炎症标志物的同时测量 PCT 可以提高这些标志物的诊断价值。此外，还需要进一步的研究来证实 PCT 在区分 IBD 疾病活动性方面的价值。

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Procalcitonin in inflammatory bowel disease: A diagnostic or prognostic marker

Serological biomarkers have been rapidly progressing as non-invasive tests for the early detection of inflammatory bowel disease (IBD). Procalcitonin (PCT) is a novel acute-phase reactant protein that is elevated in the inflammatory process, especially in bacterial infections. This study aimed to review the diagnostic value of PCT in IBD activity. However, there were controversies about the role of PCT in the detecting of IBD disease activity. Studies showed varied diagnostic cut-points (ranging from 0.13 to 1.0 ng/dl) and sensitivity up to 93 %. Although the clear role of PCT as a valuable diagnostic marker was not identified in determining disease activity, PCT measurement in addition to other inflammatory markers can improve the diagnostic value of these markers. Moreover, further studies are required to confirm PCT's value in distinguishing IBD disease activity.

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来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.