{"title":"[唑伦膦酸治疗期间下颌骨密度的动态变化]。","authors":"N S Nurieva, I G Shelegova, V A Fanakin","doi":"10.17116/stomat202410304133","DOIUrl":null,"url":null,"abstract":"<p><strong>The aim of the study: </strong>Was to investigate the dynamics of mandibular density in cancer patients during therapy with zolendronic acid.</p><p><strong>Materials and methods: </strong>The study comprised 14 patients who received zolendronic acid at a dosage of 4 mg once every 28 days for bone metastases. In all 14 patients, measurements of mandibular density values on CT scans were performed over time.</p><p><strong>Results: </strong>Using multiple linear regression analysis, a model was developed to predict the effect of the number of zolendronic acid injections «X<sub>1</sub>» on the dynamics of mandibular density «Y». The resulting formula for predicting mandibular density is Y = 5.9 X<sub>1</sub> + 49 HU.</p><p><strong>Conclusion: </strong>The model has limitations due to the study design but still can be used by oncologists and dentists to assess mandibular density in patients taking zolendronic acid.</p>","PeriodicalId":35887,"journal":{"name":"Stomatologiya","volume":"103 4","pages":"33-36"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Dynamics of mandibular density during therapy with zolendronic acid].\",\"authors\":\"N S Nurieva, I G Shelegova, V A Fanakin\",\"doi\":\"10.17116/stomat202410304133\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>The aim of the study: </strong>Was to investigate the dynamics of mandibular density in cancer patients during therapy with zolendronic acid.</p><p><strong>Materials and methods: </strong>The study comprised 14 patients who received zolendronic acid at a dosage of 4 mg once every 28 days for bone metastases. In all 14 patients, measurements of mandibular density values on CT scans were performed over time.</p><p><strong>Results: </strong>Using multiple linear regression analysis, a model was developed to predict the effect of the number of zolendronic acid injections «X<sub>1</sub>» on the dynamics of mandibular density «Y». The resulting formula for predicting mandibular density is Y = 5.9 X<sub>1</sub> + 49 HU.</p><p><strong>Conclusion: </strong>The model has limitations due to the study design but still can be used by oncologists and dentists to assess mandibular density in patients taking zolendronic acid.</p>\",\"PeriodicalId\":35887,\"journal\":{\"name\":\"Stomatologiya\",\"volume\":\"103 4\",\"pages\":\"33-36\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Stomatologiya\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.17116/stomat202410304133\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Stomatologiya","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17116/stomat202410304133","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
研究目的旨在研究癌症患者在使用唑伦膦酸治疗期间下颌骨密度的动态变化：研究对象包括14名接受唑仑膦酸治疗的骨转移患者，剂量为每28天一次，每次4毫克。在所有 14 名患者中，随时间推移对 CT 扫描的下颌骨密度值进行了测量：通过多元线性回归分析，建立了一个模型来预测唑伦膦酸注射次数 "X1 "对下颌骨密度动态 "Y "的影响。由此得出的下颌骨密度预测公式为 Y = 5.9 X1 + 49 HU：由于研究设计的原因，该模型存在一定的局限性，但仍可用于肿瘤学家和牙科医生评估服用唑伦膦酸患者的下颌骨密度。
[Dynamics of mandibular density during therapy with zolendronic acid].
The aim of the study: Was to investigate the dynamics of mandibular density in cancer patients during therapy with zolendronic acid.
Materials and methods: The study comprised 14 patients who received zolendronic acid at a dosage of 4 mg once every 28 days for bone metastases. In all 14 patients, measurements of mandibular density values on CT scans were performed over time.
Results: Using multiple linear regression analysis, a model was developed to predict the effect of the number of zolendronic acid injections «X1» on the dynamics of mandibular density «Y». The resulting formula for predicting mandibular density is Y = 5.9 X1 + 49 HU.
Conclusion: The model has limitations due to the study design but still can be used by oncologists and dentists to assess mandibular density in patients taking zolendronic acid.
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