{"title":"从南中国海采集的海绵 Phakellia fusca 中发现具有 IL-6 抑制活性的吡咯内酰胺生物碱。","authors":"","doi":"10.1016/j.phytochem.2024.114250","DOIUrl":null,"url":null,"abstract":"<div><p>Sixteen undescribed pyrrololactam alkaloids, including five 2-bromopyrrole-<em>ε</em>-lactam (<strong>1a</strong>, <strong>1b</strong>, <strong>4a</strong>, <strong>4b</strong> and <strong>5</strong>), two 3-bromopyrrole-<em>ε</em>-lactam (<strong>9</strong> and <strong>10</strong>), eight pyrrole-<em>ε</em>-lactam (<strong>2a-3</strong> and <strong>6a-8</strong>), and one pyrrole-<em>δ</em>-lactam alkaloids (<strong>11</strong>), along with three previously reported compounds (<strong>12–14</strong>) were isolated from the marine sponge <em>Phakellia fusca</em> collected in the South China Sea. The planar structures were determined by NMR and MS analyses, while the absolute configurations were clearly elucidated by comparing the experimental and calculated ECD spectra. Compounds <strong>2a</strong>, <strong>2b</strong>, <strong>4a-7b</strong>, <strong>10</strong>, <strong>12</strong> and <strong>13</strong> exhibited anti-inflammatory activity in inhibiting the production of inflammatory cytokines IL-6 in LPS-induced RAW264.7 macrophages.</p></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pyrrololactam alkaloids with IL-6 inhibitory activities from the sponge Phakellia fusca collected in the South China Sea\",\"authors\":\"\",\"doi\":\"10.1016/j.phytochem.2024.114250\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Sixteen undescribed pyrrololactam alkaloids, including five 2-bromopyrrole-<em>ε</em>-lactam (<strong>1a</strong>, <strong>1b</strong>, <strong>4a</strong>, <strong>4b</strong> and <strong>5</strong>), two 3-bromopyrrole-<em>ε</em>-lactam (<strong>9</strong> and <strong>10</strong>), eight pyrrole-<em>ε</em>-lactam (<strong>2a-3</strong> and <strong>6a-8</strong>), and one pyrrole-<em>δ</em>-lactam alkaloids (<strong>11</strong>), along with three previously reported compounds (<strong>12–14</strong>) were isolated from the marine sponge <em>Phakellia fusca</em> collected in the South China Sea. The planar structures were determined by NMR and MS analyses, while the absolute configurations were clearly elucidated by comparing the experimental and calculated ECD spectra. Compounds <strong>2a</strong>, <strong>2b</strong>, <strong>4a-7b</strong>, <strong>10</strong>, <strong>12</strong> and <strong>13</strong> exhibited anti-inflammatory activity in inhibiting the production of inflammatory cytokines IL-6 in LPS-induced RAW264.7 macrophages.</p></div>\",\"PeriodicalId\":20170,\"journal\":{\"name\":\"Phytochemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2024-08-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0031942224002875\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0031942224002875","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Pyrrololactam alkaloids with IL-6 inhibitory activities from the sponge Phakellia fusca collected in the South China Sea
Sixteen undescribed pyrrololactam alkaloids, including five 2-bromopyrrole-ε-lactam (1a, 1b, 4a, 4b and 5), two 3-bromopyrrole-ε-lactam (9 and 10), eight pyrrole-ε-lactam (2a-3 and 6a-8), and one pyrrole-δ-lactam alkaloids (11), along with three previously reported compounds (12–14) were isolated from the marine sponge Phakellia fusca collected in the South China Sea. The planar structures were determined by NMR and MS analyses, while the absolute configurations were clearly elucidated by comparing the experimental and calculated ECD spectra. Compounds 2a, 2b, 4a-7b, 10, 12 and 13 exhibited anti-inflammatory activity in inhibiting the production of inflammatory cytokines IL-6 in LPS-induced RAW264.7 macrophages.
期刊介绍：
Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.
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