Xiaoliu Liang, Hui Liu, Hu Chen, Xuqi Peng, Zhenjie Li, Minglei Teng, Yisheng Peng, Jiwei Li, Linyu Ding, Jingsong Mao, Chengchao Chu, Hongwei Cheng, Gang Liu
{"title":"封面：治疗肝细胞癌的莱茵基皮克林乳剂：塑造经动脉化疗栓塞术中的代谢信号和免疫激活作用","authors":"Xiaoliu Liang, Hui Liu, Hu Chen, Xuqi Peng, Zhenjie Li, Minglei Teng, Yisheng Peng, Jiwei Li, Linyu Ding, Jingsong Mao, Chengchao Chu, Hongwei Cheng, Gang Liu","doi":"10.1002/agt2.653","DOIUrl":null,"url":null,"abstract":"<p>This study identifies metabolic reprogramming and immunosuppression as key factors in transarterial chemoembolization (TACE) refractoriness. Rhein is optimized as a glycolytic inhibitor and immunoactivator to enhance tumor response to TACE. An oil-in-water lipiodol emulsion stabilized with Rhein nanogel holds enhanced mechanical stability, ensuring effective embolization, prolonged drug release, and potent anti-tumor immunity, presenting a new approach for TACE (e552).\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":72127,"journal":{"name":"Aggregate (Hoboken, N.J.)","volume":null,"pages":null},"PeriodicalIF":13.9000,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.653","citationCount":"0","resultStr":"{\"title\":\"Front Cover: Rhein-based Pickering emulsion for hepatocellular carcinoma: Shaping the metabolic signaling and immunoactivation in transarterial chemoembolization\",\"authors\":\"Xiaoliu Liang, Hui Liu, Hu Chen, Xuqi Peng, Zhenjie Li, Minglei Teng, Yisheng Peng, Jiwei Li, Linyu Ding, Jingsong Mao, Chengchao Chu, Hongwei Cheng, Gang Liu\",\"doi\":\"10.1002/agt2.653\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>This study identifies metabolic reprogramming and immunosuppression as key factors in transarterial chemoembolization (TACE) refractoriness. Rhein is optimized as a glycolytic inhibitor and immunoactivator to enhance tumor response to TACE. An oil-in-water lipiodol emulsion stabilized with Rhein nanogel holds enhanced mechanical stability, ensuring effective embolization, prolonged drug release, and potent anti-tumor immunity, presenting a new approach for TACE (e552).\\n\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":72127,\"journal\":{\"name\":\"Aggregate (Hoboken, N.J.)\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":13.9000,\"publicationDate\":\"2024-08-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/agt2.653\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Aggregate (Hoboken, N.J.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/agt2.653\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aggregate (Hoboken, N.J.)","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/agt2.653","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Front Cover: Rhein-based Pickering emulsion for hepatocellular carcinoma: Shaping the metabolic signaling and immunoactivation in transarterial chemoembolization
This study identifies metabolic reprogramming and immunosuppression as key factors in transarterial chemoembolization (TACE) refractoriness. Rhein is optimized as a glycolytic inhibitor and immunoactivator to enhance tumor response to TACE. An oil-in-water lipiodol emulsion stabilized with Rhein nanogel holds enhanced mechanical stability, ensuring effective embolization, prolonged drug release, and potent anti-tumor immunity, presenting a new approach for TACE (e552).
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