衰老的肾脏揭示了内皮功能障碍的内在机制

IF 14.8 1区医学 Q1 UROLOGY & NEPHROLOGY

Kidney international Pub Date : 2024-08-20 DOI:10.1016/j.kint.2024.06.020

Ubong S. Ekperikpe , Ilse S. Daehn

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引用次数: 0

摘要

Jiang等人的研究表明，肾小球内皮细胞中的Rab5效应物锌指FYVE型含21通过稳定亚细胞囊泡上的活化内皮一氧化氮合酶参与维持肾小球滤过屏障的平衡。该研究证明，含锌手指 FYVE-type 21 可通过基于囊泡的贩运调节肾小球内皮细胞中 caveolin-1 的水平，从而支持内皮一氧化氮合酶的活性。作者提供的证据表明，肾小球内皮细胞中锌指 FYVE-type containing 21 表达的减少可能在与衰老相关的肾小球滤过屏障功能障碍中发挥作用。

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Aging kidneys reveal underlying mechanisms of endothelial dysfunction

Jiang et al. show that zinc finger FYVE-type containing 21, a Rab5 effector in glomerular endothelial cells is involved in the maintenance of glomerular filtration barrier homeostasis through the stabilization of activated endothelial nitric oxide synthase on subcellular vesicles. The study demonstrates that zinc finger FYVE-type containing 21 could modulate the levels of caveolin-1 in glomerular endothelial cells using vesicle-based trafficking, thereby supporting endothelial nitric oxide synthase activity. The authors provide evidence that decreased zinc finger FYVE-type containing 21 expression in glomerular endothelial cells could play a role in aging-related glomerular filtration barrier dysfunction.

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来源期刊

Kidney international 医学-泌尿学与肾脏学

CiteScore

23.30

自引率

3.10%

发文量

490

审稿时长

3-6 weeks

期刊介绍： Kidney International (KI), the official journal of the International Society of Nephrology, is led by Dr. Pierre Ronco (Paris, France) and stands as one of nephrology's most cited and esteemed publications worldwide. KI provides exceptional benefits for both readers and authors, featuring highly cited original articles, focused reviews, cutting-edge imaging techniques, and lively discussions on controversial topics. The journal is dedicated to kidney research, serving researchers, clinical investigators, and practicing nephrologists.