白细胞介素-2在移植物抗宿主病的发病机制、预防和治疗中的作用

IF 3.7 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
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引用次数: 0

摘要

移植物抗宿主疾病(GVHD)是异基因造血细胞移植(allo-HCT)后的一种重要并发症,对患者的存活构成巨大风险。在移植患者的后期随访阶段,GVHD 也是发病率和致残率的主要原因之一,这主要是由于患者对一线类固醇的反应较低,而二线又缺乏有效的标准疗法。IL-2是GVHD复杂发病机制中的关键介质之一,有助于调节性T细胞(Tregs)和效应T细胞(Teffs)之间错综复杂的平衡。鉴于IL-2在GVHD治疗中的关键作用,多项研究对其作为一种治疗选择的潜力进行了调查。我们讨论了低剂量IL-2疗法的结果及其对Treg增殖和类固醇依赖性降低的影响。此外,我们还强调了将IL-2与其他疗法(如体外光化疗法(ECP)和Treg富集淋巴细胞输注)相结合的效果。此外,还探讨了包括改良 IL-2 复合物和 IL-2 受体阻断在内的新方法在选择性增强 Treg 功能和限制 Teff 激活方面的潜力。人们对IL-2在免疫调节中的关键作用不断加深了解,这为应用GVHD治疗和预防策略带来了美好前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of interleukin-2 in graft-versus-host disease pathogenesis, prevention and therapy

Graft-versus-host disease (GVHD) is a significant complication following allogeneic hematopoietic cell transplantation (allo-HCT), posing substantial risks to patient survival. In the late follow-up phase of transplanted patients, GVHD is also a major cause of morbidity and disability, mostly due to low response to first-line steroids and the lack of effective standard therapies in the second line.

This review provides a description of GVHD pathogenesis, with a focus on the central role of Interleukin-2 (IL-2). IL-2 is one of the critical mediators in the complex pathogenesis of GVHD, contributing to the intricate balance between regulatory T cells (Tregs) and effector T cells (Teffs). Due to this pivotal role, several studies investigate the potential of IL-2 as a therapeutic option for GVHD management. We discuss the outcomes of low-dose IL-2 therapies and their impact on Treg proliferation and steroid dependency reduction. Additionally, the effects of combining IL-2 with other treatments, such as extracorporeal photopheresis (ECP) and Treg-enriched lymphocyte infusions, are highlighted. Novel approaches, including modified IL-2 complexes and IL-2 receptor blockade, are explored for their potential in selectively enhancing Treg function and limiting Teff activation. The evolving understanding of IL-2′s pivotal role in immune regulation presents promising prospects for applying treatment and prevention strategies for GVHD.

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来源期刊
Cytokine
Cytokine 医学-免疫学
CiteScore
7.60
自引率
2.60%
发文量
262
审稿时长
48 days
期刊介绍: The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.
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