骨折相关感染血液生物标志物：诊断策略。

IF 2.2 3区医学 Q3 CRITICAL CARE MEDICINE

Injury-International Journal of the Care of the Injured Pub Date : 2024-11-01 DOI:10.1016/j.injury.2024.111823

Roman M. Natoli , Sarah Malek

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引用次数: 0

摘要

骨折相关感染是严重的术后并发症，会给患者带来沉重的负担和额外的医疗费用。尽管这些感染对治疗结果有影响，但由于目前可用的检测方法缺乏可接受的诊断参数，因此早期诊断这些感染仍具有挑战性。本综述汇编了已被评估为早期诊断工具的血液生物标志物的现有信息，并强调了其可靠性方面的挑战。为了克服这些挑战，近年来正在研究利用 "omics "技术和新型分析方法发现生物标志物的新途径。尽管这些新方法很复杂，但似乎可能是发现骨折相关感染诊断生物标志物的未来方向。

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Fracture-related infection blood-based biomarkers: Diagnostic strategies

Fracture-related infections are significant postoperative complications that carry substantial patient burden and additional healthcare costs. Despite their impact on outcome, early diagnosis of these infections remains challenging due to current available tests lacking acceptable diagnostic parameters. This review compiles existing information on blood-based biomarkers that have been evaluated as early diagnostic tools and highlights the challenges in their reliability. To begin to overcome these challenges new avenues of biomarker discovery utilizing “omics” technologies and novel analytical methods are being investigated in recent years. It appears that, despite their complexity, these newer approaches may be the future in biomarker discovery for fracture-related infection diagnosis.

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来源期刊

Injury-International Journal of the Care of the Injured 医学-急救医学

CiteScore

4.00

自引率

8.00%

发文量

699

审稿时长

96 days

期刊介绍： Injury was founded in 1969 and is an international journal dealing with all aspects of trauma care and accident surgery. Our primary aim is to facilitate the exchange of ideas, techniques and information among all members of the trauma team.