平衡医学时代的口腔微生物组、牙周病和全身性骨相关疾病。

Weiqi Hu, Shuoling Chen, Xianghui Zou, Yan Chen, Jiayu Luo, Peiliang Zhong, Dandan Ma
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引用次数: 0

摘要

背景介绍稳态是一种自我调节和动态平衡的状态,维持着生物体各系统良好的生理功能。在口腔中,宿主与口腔微生物群之间的相互作用形成了口腔微生物平衡。在口腔微生物稳态的维持下,可发生生理性骨重塑和更新。骨平衡失调是导致全身性骨相关疾病发生的关键机制。考虑到口腔微生物平衡在维持骨平衡中的重要性,目前对口腔微生物组、牙周病和全身性骨相关疾病之间的关系仍缺乏完整的认识:本综述重点探讨了口腔微生物组在牙周病和全身性骨相关疾病(如类风湿性关节炎、骨关节炎、骨质疏松症和骨髓炎)中的稳态变化、致病途径和潜在机制。此外,这篇综述还讨论了基于口腔微生物组的诊断方法,并探讨了益生菌、间充质干细胞和口腔微生物组移植作为有前景的治疗策略:本综述强调了口腔微生物平衡失调与全身性骨相关疾病之间的关联,并强调了重塑口腔微生物平衡以预防和治疗全身性骨相关疾病的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oral microbiome, periodontal disease and systemic bone-related diseases in the era of homeostatic medicine.

Background: Homeostasis is a state of self-regulation and dynamic equilibrium, maintaining the good physiological functions of each system in living organisms. In the oral cavity, the interaction between the host and the oral microbiome forms oral microbial homeostasis. Physiological bone remodeling and renewal can occur under the maintenance of oral microbial homeostasis. The imbalance of bone homeostasis is a key mechanism leading to the occurrence of systemic bone-related diseases. Considering the importance of oral microbial homeostasis in the maintenance of bone homeostasis, it still lacks a complete understanding of the relationship between oral microbiome, periodontal disease and systemic bone-related diseases.

Aim of review: This review focuses on the homeostatic changes, pathogenic routes and potential mechanisms in the oral microbiome in periodontal disease and systemic bone-related diseases such as rheumatoid arthritis, osteoarthritis, osteoporosis and osteomyelitis. Additionally, this review discusses oral microbiome-based diagnostic approaches and explores probiotics, mesenchymal stem cells, and oral microbiome transplantation as promising treatment strategies.

Key scientific concepts of review: This review highlights the association between oral microbial homeostasis imbalance and systemic bone-related diseases, and highlights the possibility of remodeling oral microbial homeostasis for the prevention and treatment of systemic bone-related diseases.

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