慢性中风幸存者的白天过度嗜睡、炎症和血小板能量代谢:一项试点研究

IF 2.2 4区 医学 Q1 NURSING
Nursing Research Pub Date : 2025-01-01 Epub Date: 2024-08-16 DOI:10.1097/NNR.0000000000000773
Christine R Hoch, N Jennifer Klinedinst
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引用次数: 0

摘要

背景:白天过度嗜睡是一种普遍且持续的症状,会对中风幸存者的生理和心理造成不良影响。中风后白天过度嗜睡的机制尚不完全清楚。慢性全身性炎症可能会导致线粒体功能受损,从而降低细胞能量代谢,这可能会导致中风幸存者出现白天过度嗜睡的症状:本试验性研究旨在评估全身性炎症和细胞能量代谢与脑卒中后白天过度嗜睡之间的关系:这项描述性试验研究探讨了 22 名慢性中风幸存者白天过度嗜睡、全身炎症和血小板有氧能量代谢之间的关系。埃普沃思嗜睡量表用于测量白天过度嗜睡。通过评估促炎细胞因子 IL-6、IL-1β 和 TNF-α 以及炎症标志物 C 反应蛋白来测量全身炎症。有氧能量代谢通过评估血小板的耗氧率进行测量。简单线性回归用于检验耗氧率和炎症对白天过度嗜睡的影响。相关性采用 Spearman rho 相关系数进行分析:结果:27.3%的样本发现白天过度嗜睡。全身炎症与女性白天过度嗜睡有关,但与男性无关。我们发现白天过度嗜睡与血小板的能量代谢没有明显关系。然而,白天过度嗜睡者的所有耗氧量在数量上都更高:讨论:全身性炎症可能与白天过度嗜睡症状有关,对女性的影响尤为明显。讨论:全身性炎症可能与白天过度嗜睡症状有关,对女性的影响尤为明显,今后需要进行更大规模的研究,进一步探讨脑卒中后白天过度嗜睡与全身性炎症的性别双态关系。较高的血小板耗氧率可能表明中风后白天过度嗜睡者对能量的需求更高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Excessive Daytime Sleepiness, Inflammation, and Platelet Energy Metabolism in Chronic Stroke Survivors: A Pilot Study.

Background: Excessive daytime sleepiness is a prevalent and sustained symptom that contributes to untoward physiological and psychological outcomes among stroke survivors. Mechanisms of excessive daytime sleepiness poststroke are not fully understood. Chronic systemic inflammation may contribute to impaired mitochondrial functioning and thereby reduce cellular energy metabolism, which may contribute to symptoms of excessive daytime sleepiness in stroke survivors.

Objectives: This pilot study aimed to assess the relationship between systemic inflammation and cellular energy metabolism to poststroke excessive daytime sleepiness.

Methods: This descriptive pilot study explored the relationship between excessive daytime sleepiness, systemic inflammation, and aerobic energy metabolism of platelets in 22 chronic stroke survivors. The Epworth Sleepiness Scale was used to measure excessive daytime sleepiness. Systemic inflammation was measured by assessing pro-inflammatory cytokines interleukin-6, interleukin-1β, and tumor necrosis factor-alpha and the inflammatory marker C-reactive protein. Aerobic energy metabolism was measured by assessing oxygen consumption rates of platelets. Simple linear regression was used to test the influence of oxygen consumption rates and inflammation on excessive daytime sleepiness. Correlations were analyzed using Spearman rho correlation coefficients.

Results: Excessive daytime sleepiness was recognized in 27.3% of the sample. Systemic inflammation was associated with excessive daytime sleepiness in women but not men. We found no significant relationship between excessive daytime sleepiness and energy metabolism of platelets. However, all oxygen consumption rates were numerically higher in persons with excessive daytime sleepiness.

Discussion: Systemic inflammation may be related to excessive daytime sleepiness symptoms with a notable effect among women. Future larger studies are needed to further explore the sexually dimorphic relationship of poststroke excessive daytime sleepiness to systemic inflammation. Numerically higher platelet oxygen consumption rates may indicate higher energy demands for stroke survivors with excessive daytime sleepiness.

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来源期刊
Nursing Research
Nursing Research 医学-护理
CiteScore
3.60
自引率
4.00%
发文量
102
审稿时长
6-12 weeks
期刊介绍: Nursing Research is a peer-reviewed journal celebrating over 60 years as the most sought-after nursing resource; it offers more depth, more detail, and more of what today''s nurses demand. Nursing Research covers key issues, including health promotion, human responses to illness, acute care nursing research, symptom management, cost-effectiveness, vulnerable populations, health services, and community-based nursing studies. Each issue highlights the latest research techniques, quantitative and qualitative studies, and new state-of-the-art methodological strategies, including information not yet found in textbooks. Expert commentaries and briefs are also included. In addition to 6 issues per year, Nursing Research from time to time publishes supplemental content not found anywhere else.
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