Sara I Taha, Lamyaa Salem, Rasha Mohamad Hassan, Mahy El-Bassiouny, Marwa Hamdy, Marwa Adham El-Mohamdy
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引用次数: 0
摘要
目的研究眶周黑色素沉着(POM)与胰岛素抵抗(IR)和维生素 D 血清水平之间可能存在的关联:在这项试验性病例对照研究中,我们纳入了 100 名患有眶周黑色素沉着症的成年患者和 100 名年龄与性别匹配的健康对照组受试者。比较病例和对照组的维生素 D 水平和 IR 指数(即稳态模型评估-胰岛素抵抗 [HOMA-IR]、甘油三酯/高密度脂蛋白胆固醇(TG/HDL-c)比率、脂肪连接素/瘦素(A/L)比率):HOMA-IR和TG/HDL-c比值与POM严重程度呈显著正相关,而维生素D和A/L比值与POM严重程度呈显著负相关:结论:POM 与 IR 指数和维生素 D 缺乏有关。然而,POM、IR 和维生素 D 之间的确切因果关系仍有待确定。不过,这项试点研究的结果表明,POM有可能成为这些代谢紊乱的皮肤非侵入性标志物,有助于早期发现和治疗这些疾病。
Periorbital melanosis and its possible association with insulin resistance and vitamin D deficiency: A pilot case-control study.
Objective: To investigate the possible association of periorbital melanosis (POM) with insulin resistance (IR) and vitamin D serum levels.
Methods: In this pilot, case-control study, we included 100 adult patients with POM and 100 age- and sex-matched healthy control subjects. Vitamin D levels and IR indices (i.e., homeostatic model assessment-insulin resistance [HOMA-IR], triglycerides/high-density lipoprotein cholesterol (TG/HDL-c) ratio, adiponectin/leptin (A/L) ratio) were compared between cases and controls.
Results: Compared with controls, POM cases had significantly higher values of HOMA-IR and TG/HDL-c ratio, and significantly lower values of A/L and vitamin D. HOMA-IR and TG/HDL-c ratio were statistically significantly positively correlated with POM severity while Vitamin D and A/L ratio were statistically significantly negatively correlated.
Conclusion: POM was associated with indices of IR and vitamin D deficiency. However, the exact causal link among POM, IR, and vitamin D needs to be established. However, the results of this pilot study suggest that POM may have potential as a cutaneous non-invasive marker of these metabolic disorders which would assist in detecting and treating them at an early stage.
期刊介绍:
_Journal of International Medical Research_ is a leading international journal for rapid publication of original medical, pre-clinical and clinical research, reviews, preliminary and pilot studies on a page charge basis.
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Print ISSN: 0300-0605