从脂肪醇和乙二醇中多克两步合成二氟甲基醚

IF 1.7 4区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Fluorine Chemistry Pub Date : 2024-08-01 DOI:10.1016/j.jfluchem.2024.110330

Kirill I. Petko, Andrey A. Filatov, Yurii L. Yagupolskii

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引用次数: 0

摘要

对一系列脂肪醇和乙二醇研究了一种合成烷基（二氟甲基）醚的简便方法，包括 O-甲酰基衍生物的后续氯化和氟化阶段。伯醇和仲醇可以高产率转化为相应的 O-二氟甲基衍生物，而 1,3-丙二醇、二乙二醇和季戊四醇的多二氟甲基衍生物只能通过这种方法成功获得。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Multigram two-step synthesis of difluoromethyl ethers from aliphatic alcohols and glycols

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Multigram two-step synthesis of difluoromethyl ethers from aliphatic alcohols and glycols

A convenient method for synthesis of alkyl(difluoromethyl)ethers, including subsequent stages of chlorination and fluorination of the O-formyl derivatives was investigated on series of aliphatic alcohols and glycols. Primary and secondary alcohols are converted to the corresponding O-difluoromethyl derivatives in high yield, polydifluoromethyl derivatives of 1,3-propyleneglycol, diethyleneglycole and pentaerythritol can only be successfully obtained with this procedure.

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来源期刊

Journal of Fluorine Chemistry 化学-无机化学与核化学

CiteScore

3.80

自引率

10.50%

发文量

审稿时长

33 days

期刊介绍： The Journal of Fluorine Chemistry contains reviews, original papers and short communications. The journal covers all aspects of pure and applied research on the chemistry as well as on the applications of fluorine, and of compounds or materials where fluorine exercises significant effects. This can include all chemistry research areas (inorganic, organic, organometallic, macromolecular and physical chemistry) but also includes papers on biological/biochemical related aspects of Fluorine chemistry as well as medicinal, agrochemical and pharmacological research. The Journal of Fluorine Chemistry also publishes environmental and industrial papers dealing with aspects of Fluorine chemistry on energy and material sciences. Preparative and physico-chemical investigations as well as theoretical, structural and mechanistic aspects are covered. The Journal, however, does not accept work of purely routine nature. For reviews and special issues on particular topics of fluorine chemistry or from selected symposia, please contact the Regional Editors for further details.