螺旋环状环戊并吡啶的高效合成路线

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2024-08-14 DOI:10.1016/j.tetlet.2024.155250

Yuan-Hong Yang , Qun-Zheng Zhang , Si-Chang Wang , Yu-Qing Shan , Cong-Yu Ke

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引用次数: 0

摘要

吡啶螺环化合物在药物设计和开发中发挥着重要作用。本文合成了一种新型螺环环戊吡啶化合物。根据逆合成分析，以市场上可买到的 2-氯-6-甲氧基吡啶为起始原料，通过八步反应过程合成了目标分子。特别强调了两个最具挑战性的步骤：选择性内吉耦合和羰基还原。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

An efficient route for synthesis of spirocyclic cyclopentapyridines

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An efficient route for synthesis of spirocyclic cyclopentapyridines

Pyridine spirocycles play an important role in drug design and development. In this paper, a novel spirocyclic cyclopentapyridine compound was synthesized. Based on retrosynthesis analysis, commercially available 2-chloro-6-methoxypyridine was used as the starting material for the synthesis of the target molecule, accomplished through an eight-step reaction process. Particular emphasis was placed on the two most challenging steps: selective Negishi coupling and carbonyl reduction.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.