马弥漫性精原细胞瘤的形态学和免疫组化特征:病例报告。

IF 1.6 3区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Lucas Andrê Silva Batista, Dinamérico de Alencar Santos Júnior, Alexandra Soares Rodrigues, Artur Azevedo Menezes, Maria Jussara Rodrigues do Nascimento, Glauco Jose Nogueira de Galiza, Antônio Flávio de Medeiros Dantas, Maria Talita Soares Frade
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引用次数: 0

摘要

本研究描述了一例 16 岁雄性混血马弥漫性精原细胞瘤的形态学和免疫组化特征。据马主称,该马的左侧睾丸在两个月内逐渐增大。触诊时,睾丸质地坚硬,对数字压力不敏感,与阴囊粘连,大小为 16 厘米×8 厘米。在超声波检查中,睾丸质地不均匀,有低回声区,纵隔未见。因此,对其进行了双侧睾丸切除术。手术后发现,患侧睾丸呈 9 厘米×7 厘米×3.5 厘米的坚实肿块。组织学检查发现,肿瘤为多叶、无包膜、浸润性肿块,取代了曲细精管,由多角形细胞组成,排列在从粘连到松散粘连的套膜中,由稀少的纤维基质支撑。在免疫组化检查中,肿瘤细胞对 OCT4 和 C-KIT 呈阳性免疫标记。在本报告中,体格检查和超声波检查是治疗该病例的基础,最终诊断是在组织病理学和免疫组化检查后做出的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Morphological and immunohistochemical characteristics of diffuse seminoma in horses: A case report.

The present study describes the morphological and immunohistochemical characteristics of a case of diffuse seminoma in a 16-year-old male mixed-breed horse. According to the owner, the animal's left testicle had been gradually increasing in size over a period of 2 months. On palpation, the testicle had a firm consistency, with no sensitivity to digital pressure, was adhered to the scrotum and measuring 16 cm × 8 cm. In the ultrasound examination, it presented a heterogeneous texture and areas of hypoechogenic echogenicity without visualization of the mediastinum. Therefore, the bilateral orchiectomy was performed. After the surgical procedure, it was found that the affected testicle presented a firm mass measuring 9 cm × 7 cm × 3.5 cm. Histologically, a multilobulated, non-encapsulated and invasive tumour mass was found, which replaced the seminiferous tubules, consisting of polygonal cells arranged in a mantle that varied from cohesive to loosely cohesive, supported by a scarce fibrous stroma. In the immunohistochemical examination, the neoplastic cells showed positive immunolabelling for OCT4 and C-KIT. In this report, the physical examination combined with the ultrasonographic examination were fundamental to the therapeutic management of the case, and the final diagnosis was made after histopathological and immunohistochemical tests.

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来源期刊
Reproduction in Domestic Animals
Reproduction in Domestic Animals 农林科学-奶制品与动物科学
CiteScore
3.00
自引率
5.90%
发文量
238
审稿时长
4-8 weeks
期刊介绍: The journal offers comprehensive information concerning physiology, pathology, and biotechnology of reproduction. Topical results are currently published in original papers, reviews, and short communications with particular attention to investigations on practicable techniques. Carefully selected reports, e. g. on embryo transfer and associated biotechnologies, gene transfer, and spermatology provide a link between basic research and clinical application. The journal applies to breeders, veterinarians, and biologists, and is also of interest in human medicine. Interdisciplinary cooperation is documented in the proceedings of the joint annual meetings. Fields of interest: Animal reproduction and biotechnology with special regard to investigations on applied and clinical research.
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