大鼠发育过程中体重增加的变化。

IF 1.3 4区 农林科学 Q2 VETERINARY SCIENCES
Pablo Vázquez-Borsetti
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引用次数: 0

摘要

大鼠是生物医学中使用最多的动物模型之一。传统上,人们利用体重增加来衡量大鼠的发育情况,并对不同物种进行比较。许多研究对大鼠的发育进行了纵向分析,重点是体重增加分析。鉴于这些模式的高度可变性,来自单一实验室的实验数据可能并不可靠,无法进行普遍的估计。本研究旨在分析不同因素对大鼠发育过程中体重增加模式的影响。通过文献调查,我们建立了一个数据库,其中包括来自 15 项纵向研究的近 300 个年龄和体重数据点。该数据库包括出生前和出生后的数据。利用贡珀兹方程对数据进行分析,从而建立了一个描述大鼠发育过程的综合模型。在发育后期,生长模式的差异变得越来越明显,性别和品系之间的最大渐近线差异显著。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Variability in rat weight gain during development.

The rat is one of the most employed animal models in biomedicine. Traditionally, weight gain has been utilized to gauge development and compare across species. Numerous studies have conducted longitudinal analyses of rat development, with emphasis on weight gain analysis. Given the high variability in these patterns, experimental data from a single laboratory may not be reliable for generalized estimation. This study aimed to analyze the effect of different factors on the pattern of weight gain during rat development. A literature survey was conducted to compile a database comprising nearly 300 data points of age and weight from 15 longitudinal studies. The database comprised both pre- and postnatal data. Utilizing the Gompertz equation, the data was analyzed to formulate a comprehensive model describing rat development. Differences in growth patterns became increasingly evident at later developmental stages, when significant differences in the maximum asymptote between sexes and strains were reached.

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来源期刊
Laboratory Animals
Laboratory Animals 生物-动物学
CiteScore
4.90
自引率
8.30%
发文量
64
审稿时长
6-12 weeks
期刊介绍: The international journal of laboratory animal science and welfare, Laboratory Animals publishes peer-reviewed original papers and reviews on all aspects of the use of animals in biomedical research. The journal promotes improvements in the welfare or well-being of the animals used, it particularly focuses on research that reduces the number of animals used or which replaces animal models with in vitro alternatives.
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