Lin28A和Lin28B在癌症中的作用超越了Let-7。

IF 3.5 4区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Sandra Cotino-Nájera, Enrique García-Villa, Samantha Cruz-Rosales, Patricio Gariglio, José Díaz-Chávez
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引用次数: 0

摘要

Lin28A和Lin28B是同源的RNA结合蛋白,它们通过调节肿瘤抑制因子Let-7的microRNA家族,在发育和癌症中发挥着重要作用。虽然 Lin28A 和 Lin28B 与 Let-7 抑制剂在功能上有一些相似之处,但它们也有不同的表达模式和生物功能。越来越多的证据表明,Lin28A 和 Lin28B 对癌症干细胞特性、上皮-间充质转化、代谢重编程以及癌症的其他特征有不同的影响。因此,了解Lin28A和Lin28B旁系亲属在特定癌症环境中的过表达非常重要。在这篇综述中,我们总结了 Lin28A 和 Lin28B 的主要异同点、它们在不同细胞过程中的意义以及它们在不同类型癌症中的作用。此外,我们还提供了每种 Lin28 旁系亲属的其他特定靶点的证据,以及促进或抑制其表达的 lncRNA 和 miRNA,以及这如何影响癌症的发生和发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of Lin28A and Lin28B in cancer beyond Let-7.

Lin28A and Lin28B are paralogous RNA-binding proteins that play fundamental roles in development and cancer by regulating the microRNA family of tumor suppressor Let-7. Although Lin28A and Lin28B share some functional similarities with Let-7 inhibitors, they also have distinct expression patterns and biological functions. Increasing evidence indicates that Lin28A and Lin28B differentially impact cancer stem cell properties, epithelial-mesenchymal transition, metabolic reprogramming, and other hallmarks of cancer. Therefore, it is important to understand the overexpression of Lin28A and Lin28B paralogs in specific cancer contexts. In this review, we summarize the main similarities and differences between Lin28A and Lin28B, their implications in different cellular processes, and their role in different types of cancer. In addition, we provide evidence of other specific targets of each lin28 paralog, as well as the lncRNAs and miRNAs that promote or inhibit its expression, and how this impacts cancer development and progression.

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来源期刊
FEBS Letters
FEBS Letters 生物-生化与分子生物学
CiteScore
7.00
自引率
2.90%
发文量
303
审稿时长
1.0 months
期刊介绍: FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.
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