从肺细胞角度看结缔组织病相关间质性肺病发病机制的研究进展。

IF 9.2 1区医学 Q1 IMMUNOLOGY

Autoimmunity reviews Pub Date : 2024-07-01 DOI:10.1016/j.autrev.2024.103600

Shuyi Shen, Ming Hu, Yi Peng, Yi Zheng, Rong Zhang

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引用次数: 0

摘要

肺部是导致结缔组织病（CTD）患者发病率和死亡率增加的主要因素，经常表现为 CTD 相关性间质性肺病（ILD）。目前，还缺乏对与 CTD-ILD 发病有关的肺细胞的全面描述。本综述利用人类肺细胞图谱（HLCA）和空间多组学图谱，从肺细胞的角度探讨 CTD-ILD 发病机制研究的进展。这有助于更精确地定位疾病部位和更系统地考虑疾病进展，为进一步的机理研究和靶向治疗提供支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Research Progress in pathogenesis of connective tissue disease-associated interstitial lung disease from the perspective of pulmonary cells

The lungs are a principal factor in the increased morbidity and mortality observed in patients with Connective Tissue Disease (CTD), frequently presenting as CTD-associated Interstitial Lung Disease (ILD). Currently, there is a lack of comprehensive descriptions of the pulmonary cells implicated in the development of CTD-ILD. This review leverages the Human Lung Cell Atlas (HLCA) and spatial multi-omics atlases to discuss the advancements in research on the pathogenesis of CTD-ILD from a pulmonary cell perspective. This facilitates a more precise localization of disease sites and a more systematic consideration of disease progression, supporting further mechanistic studies and targeted therapies.

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来源期刊

Autoimmunity reviews 医学-免疫学

CiteScore

24.70

自引率

4.40%

发文量

164

审稿时长

21 days

期刊介绍： Autoimmunity Reviews is a publication that features up-to-date, structured reviews on various topics in the field of autoimmunity. These reviews are written by renowned experts and include demonstrative illustrations and tables. Each article will have a clear "take-home" message for readers. The selection of articles is primarily done by the Editors-in-Chief, based on recommendations from the international Editorial Board. The topics covered in the articles span all areas of autoimmunology, aiming to bridge the gap between basic and clinical sciences. In terms of content, the contributions in basic sciences delve into the pathophysiology and mechanisms of autoimmune disorders, as well as genomics and proteomics. On the other hand, clinical contributions focus on diseases related to autoimmunity, novel therapies, and clinical associations. Autoimmunity Reviews is internationally recognized, and its articles are indexed and abstracted in prestigious databases such as PubMed/Medline, Science Citation Index Expanded, Biosciences Information Services, and Chemical Abstracts.