累及中枢神经系统的髓外慢性期慢性髓性白血病(CML):病例报告

EJHaem Pub Date : 2024-06-25 DOI:10.1002/jha2.967
Akshay Deshpande, Dina Osman, Vidhya Murthy, Hayder Hussein
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引用次数: 0

摘要

慢性髓性白血病(CML)通常被描述为一种局限于骨髓的疾病,很少有髓外受累的报道。文献中将慢性骨髓性白血病的中枢神经系统受累描述为白血病阶段的一种侵袭性疾病,或先于髓质鼓风危象,或与髓质鼓风危象并存,或见于长期接受伊马替尼治疗的患者。对这一患者群体的治疗尚未达成共识,疗效仍然不佳。我们在此提交一份非常罕见的慢性 CML 中枢神经系统受累的报告,患者在确诊时出现颅内压升高和颅神经麻痹。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Extramedullary chronic phase chronic myeloid leukaemia (CML) involving the central nervous system: A case report

Extramedullary chronic phase chronic myeloid leukaemia (CML) involving the central nervous system: A case report

Chronic myeloid leukaemia (CML) has been classically described as a disease restricted to the bone marrow with very few reports of extramedullary involvement. CNS involvement with CML has been described in the literature as an aggressive disease in the leukaemic phase either preceding or coexisting with medullary blast crisis or seen in patients with long-term Imatinib therapy. No treatment consensus exists for this patient group and outcomes remain poor. We hereby present a very rare report of CNS involvement with chronic phase CML at diagnosis in a patient who presented with raised intracranial pressure and cranial nerve palsies.

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