Nan Wang, Chunlei Yin, Ruiqi Feng, Rong Jia, Liguo Zhou, Wenyu Wu, Haiyan Yu, Yuan Ye, Zhiting Gong, Lijuan Li
{"title":"分析患有 2 型糖尿病的精神分裂症患者的肠道微生物群。","authors":"Nan Wang, Chunlei Yin, Ruiqi Feng, Rong Jia, Liguo Zhou, Wenyu Wu, Haiyan Yu, Yuan Ye, Zhiting Gong, Lijuan Li","doi":"10.5152/alphapsychiatry.2024.231302","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Our goal is to examine the correlation between gut microbiota and the cooccurrence of schizophrenia and type 2 diabetes.</p><p><strong>Methods: </strong>We conducted a study on the intestinal microbiota of 4 distinct groups: simple schizophrenia group (SC), schizophrenia with type 2 diabetes group (TS), type 2 diabetes group (T2DM), and normal population control group (HC), comprising a total of 35 subjects.</p><p><strong>Results: </strong>The bacteria phyla <i>Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria,</i> and <i>Verrucobacteria</i> were consistently present across all 4 groups. Significantly higher intestinal microbiota richness was observed in the T2DM compared to the other group, and the intestinal microbiota richness in TS significantly lower than that of the SC.</p><p><strong>Conclusion: </strong>Our study suggests that the presence of type 2 diabetes in individuals with schizophrenia may affect the composition of their gut microbiota. We hypothesize that the concurrent existence of both diseases could potentially lead to alterations in the structure of gut microbiota, potentially influencing treatment effectiveness and outcomes.</p>","PeriodicalId":72151,"journal":{"name":"Alpha psychiatry","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11322711/pdf/","citationCount":"0","resultStr":"{\"title\":\"Analysis of Intestinal Microbiota in Schizophrenic Patients with Type 2 Diabetes Mellitus.\",\"authors\":\"Nan Wang, Chunlei Yin, Ruiqi Feng, Rong Jia, Liguo Zhou, Wenyu Wu, Haiyan Yu, Yuan Ye, Zhiting Gong, Lijuan Li\",\"doi\":\"10.5152/alphapsychiatry.2024.231302\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Our goal is to examine the correlation between gut microbiota and the cooccurrence of schizophrenia and type 2 diabetes.</p><p><strong>Methods: </strong>We conducted a study on the intestinal microbiota of 4 distinct groups: simple schizophrenia group (SC), schizophrenia with type 2 diabetes group (TS), type 2 diabetes group (T2DM), and normal population control group (HC), comprising a total of 35 subjects.</p><p><strong>Results: </strong>The bacteria phyla <i>Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria,</i> and <i>Verrucobacteria</i> were consistently present across all 4 groups. Significantly higher intestinal microbiota richness was observed in the T2DM compared to the other group, and the intestinal microbiota richness in TS significantly lower than that of the SC.</p><p><strong>Conclusion: </strong>Our study suggests that the presence of type 2 diabetes in individuals with schizophrenia may affect the composition of their gut microbiota. We hypothesize that the concurrent existence of both diseases could potentially lead to alterations in the structure of gut microbiota, potentially influencing treatment effectiveness and outcomes.</p>\",\"PeriodicalId\":72151,\"journal\":{\"name\":\"Alpha psychiatry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11322711/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alpha psychiatry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5152/alphapsychiatry.2024.231302\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alpha psychiatry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5152/alphapsychiatry.2024.231302","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Analysis of Intestinal Microbiota in Schizophrenic Patients with Type 2 Diabetes Mellitus.
Objective: Our goal is to examine the correlation between gut microbiota and the cooccurrence of schizophrenia and type 2 diabetes.
Methods: We conducted a study on the intestinal microbiota of 4 distinct groups: simple schizophrenia group (SC), schizophrenia with type 2 diabetes group (TS), type 2 diabetes group (T2DM), and normal population control group (HC), comprising a total of 35 subjects.
Results: The bacteria phyla Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria, and Verrucobacteria were consistently present across all 4 groups. Significantly higher intestinal microbiota richness was observed in the T2DM compared to the other group, and the intestinal microbiota richness in TS significantly lower than that of the SC.
Conclusion: Our study suggests that the presence of type 2 diabetes in individuals with schizophrenia may affect the composition of their gut microbiota. We hypothesize that the concurrent existence of both diseases could potentially lead to alterations in the structure of gut microbiota, potentially influencing treatment effectiveness and outcomes.
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