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In this study, a comprehensive analysis of phytoconstituents in neuropathic pain is carried out to understand their mechanism in preventing the disease.</p><p><strong>Method: </strong>The current search is done in the databases of Google Scholar, PubMed Central, ScienceDirect, and Scopus using the keywords: neuropathic pain, phytoconstituents as analgesics, physiological effects of medicinal plants, and natural products, to find the most relevant articles of the last 10 years.</p><p><strong>Result: </strong>Out of 125 articles, 112 were included in this study, which revealed that several phytoconstituents inhibit several biomarkers responsible for neuropathic pain. Moreover, this review highlights the underlying molecular pathways and targets through which these bioactive compounds exert their therapeutic effects, emphasizing their potential as novel pharmacological agents.</p><p><strong>Conclusion: </strong>This study concludes that phytoconstituents may possess potential applications in managing neuropathic pain and could be effectively used as an alternative approach to mitigate the condition with enhanced risk of safety and tolerability.</p>","PeriodicalId":93930,"journal":{"name":"Central nervous system agents in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Unveiling the Applications of Phytoconstituents in Neuropathic Pain.\",\"authors\":\"Rimjhim Priyanshi, Anjana Sharma, Shobhit Kumar, Arpana Gupta, Bhupesh Sharma, Nitin Sharma\",\"doi\":\"10.2174/0118715249312031240803190651\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Neuropathic pain is a complex chronic condition resulting from the damage or dysfunction of the nervous system. 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引用次数: 0
摘要
背景:神经性疼痛是一种复杂的慢性疾病,由神经系统损伤或功能障碍引起。传统疗法的疗效有限,而且往往会产生各种不良反应。因此,探索替代疗法(如植物成分)缓解神经病理性疼痛的潜力可能具有重大意义:本综述系统研究了各种植物成分在调节神经病理性疼痛方面的不同作用和机制。本研究对植物成分在神经病理性疼痛中的作用进行了全面分析,以了解其预防疾病的机制:方法:在 Google Scholar、PubMed Central、ScienceDirect 和 Scopus 等数据库中以神经性疼痛、作为镇痛剂的植物成分、药用植物的生理效应和天然产品为关键词进行检索,以找到过去 10 年中最相关的文章:结果:在125篇文章中,有112篇被纳入本研究,其中揭示了几种植物成分可抑制导致神经病理性疼痛的几种生物标志物。此外,这篇综述还强调了这些生物活性化合物发挥治疗作用的潜在分子途径和靶点,强调了它们作为新型药剂的潜力:本研究的结论是,植物成分可能具有治疗神经病理性疼痛的潜在用途,可有效用作缓解神经病理性疼痛的替代方法,同时提高安全性和耐受性。
Unveiling the Applications of Phytoconstituents in Neuropathic Pain.
Background: Neuropathic pain is a complex chronic condition resulting from the damage or dysfunction of the nervous system. Conventional therapies offer limited success and often come with various adverse effects. Therefore, the exploration of alternative therapies, such as phytoconstituents, may be of substantial interest for their potential to alleviate neuropathic pain.
Objectives: This review systematically examines the diverse roles and mechanisms of various phytoconstituents in modulating neuropathic pain. In this study, a comprehensive analysis of phytoconstituents in neuropathic pain is carried out to understand their mechanism in preventing the disease.
Method: The current search is done in the databases of Google Scholar, PubMed Central, ScienceDirect, and Scopus using the keywords: neuropathic pain, phytoconstituents as analgesics, physiological effects of medicinal plants, and natural products, to find the most relevant articles of the last 10 years.
Result: Out of 125 articles, 112 were included in this study, which revealed that several phytoconstituents inhibit several biomarkers responsible for neuropathic pain. Moreover, this review highlights the underlying molecular pathways and targets through which these bioactive compounds exert their therapeutic effects, emphasizing their potential as novel pharmacological agents.
Conclusion: This study concludes that phytoconstituents may possess potential applications in managing neuropathic pain and could be effectively used as an alternative approach to mitigate the condition with enhanced risk of safety and tolerability.